Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/9/1999
Publication Date: N/A
Citation: Interpretive Summary: There is urgent need for new sources of antifungal agents. Fungi that kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The fungus Gliocladium catenulatum produced antifungal agents that strongly inhibited the growth of Aspergillus flavus, a fungal pathogen of corn and an opportunistic pathogen of humans. Chemical studies revealed that some of these antifungal metabolites are new to science while others represent known compounds. Opportunistic fungal infections have become increasingly common in recent years and new classes of environmentally friendly agricultural fungicides are also needed. This information is useful to companies looking for sources of new antifungal compounds, as well as to scientists interested in microbial ecology.
Technical Abstract: Four new compounds (1-4) have been isolated from solid-substrate fermentation cultures of the sclerotial mycoparasite Gliocladium catenulatum. The structures of verticillins D (1), E (2), and F (3) were assigned on the basis of MS and NMR data and chemical derivatization. The structure of glisoprenin C (4) was assigned on the basis of MS and NMR results, together with comparison of its spectral data to those of the known compound glisoprenin A (6).