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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Toxicology & Mycotoxin Research » Research » Publications at this Location » Publication #390271

Research Project: Eliminating Fusarium Mycotoxin Contamination of Corn by Targeting Fungal Mechanisms and Adaptations Conferring Fitness in Corn and Toxicology and Toxinology Studies of Mycotoxins

Location: Toxicology & Mycotoxin Research

Title: A novel approach against Salmonella: A review of polymeric nanoparticle vaccines for broilers and layers

item ACEVEDO-VILLANUEVA, KEILA - University Of Georgia
item AKERLE, GABRIEL - University Of Georgia
item AL HAKEEM, WALID GHAZI - University Of Georgia
item RENU, SANKAR - The Ohio State University
item Shanmugasundaram, Revathi
item SELVARAJ, RAMESH - University Of Georgia

Submitted to: Vaccines
Publication Type: Review Article
Publication Acceptance Date: 9/11/2021
Publication Date: 9/18/2021
Citation: Acevedo-Villanueva, K.A., Akerle, G.O., Al Hakeem, W., Renu, S., Shanmugasundaram, R., Selvaraj, R. 2021. A novel approach against Salmonella: A review of polymeric nanoparticle vaccines for broilers and layers. Vaccines. 9(9):1041.

Interpretive Summary: Biodegradable nanoparticles for poultry, much progress is still needed to commercialize their use. Evidently, there are still many challenges to overtake with biodegradable nanomaterials, but they hold much potential as nanocarrier delivery systems. It is evident that the use of polymeric nanoparticle vaccines for poultry is in a premature stage, but they have shown favorable results for the oral delivery of antigens against pathogens like Salmonella. Polymeric nanoparticle vaccines have shown to be safe for broilers and layers, capable of eliciting a substantial and antigen-specific cellular and humoral immune response in broilers and layers, and capable of reducing the intestinal Salmonella load in broilers and layers. Future research should explore a) altering the vaccine’s compositions with proteins from different, yet prevalent, Salmonella serovars or different immunogenic adjuvants, b) further exploring the vaccines optimal age and dose, c) further studying the vaccines potential for different mass vaccination methods and possible different outcomes, d) evaluating the vaccines capability to decrease Salmonella colonization, and can even consider e) exploring the T-cell subsets that are involved in the immune response against Salmonella upon administration of vaccine to better understand its mechanism of action.

Technical Abstract: This work discusses the present-day limitations that current commercial Salmonella vaccines for broilers and layers face and explores a novel approach towards poultry vaccination using biodegradable nanoparticle vaccines against Salmonella. With the increasing global population and poultry production and consumption, Salmonella is a potential health-risk source for humans. The oral administration of killed or inactivated vaccines would provide a better alternative to the currently commercially available Salmonella vaccines for poultry. However, there are currently no commercial oral-killed vaccines against Salmonella for use in broilers or layers. There is a need for novel and effective interventions in the poultry industry. Polymeric nanoparticles could give way to an effective mass-administered mucosal vaccination method for Salmonella. The scope of this work is limited to polymeric nanoparticles against Salmonella for use in broilers and layers. This review is based on the information available at the time of the investigation.