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ARS Home » Southeast Area » Gainesville, Florida » Center for Medical, Agricultural and Veterinary Entomology » Chemistry Research » Research » Publications at this Location » Publication #387774
Research Project: Molecular and Biochemical Characterization of Biotic and Abiotic Stress on Plant Defense Responses in Maize

Location: Chemistry Research

Title: Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism

Author
item BERGER, ANTOINE - University Of Florida
item LATIMER, SCOTT - University Of Florida
item STUTTS, LAUREN - University Of Florida
item SOUBEYRAND, ERIC - University Of Florida
item Block, Anna
item BASSET, GILLES - University Of Florida

Submitted to: Current Opinion in Plant Biology
Publication Type: Review Article
Publication Acceptance Date: 12/1/2021
Publication Date: 1/10/2022
Citation: Berger, A., Latimer, S., Stutts, L.R., Soubeyrand, E., Block, A.K., Basset, G.J. 2022. Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism. Current Opinion in Plant Biology. 66, 102165. https://doi.org/10.1016/j.pbi.2021.102165.
DOI: https://doi.org/10.1016/j.pbi.2021.102165

Interpretive Summary:

Technical Abstract: About 25% of 4-hydroxybenzoate that serves as an aromatic ring precursor of the vital respiratory cofactor and liposoluble antioxidant ubiquinone (coenzyme Q), originates from the catabolism of the flavonol, kaempferol. Biochemical and genetic evidence indicates that the release of 4-hydroxybenzoate from kaempferol is catalyzed by heme-dependent peroxidases, and that 3-O-glycosylations of kaempferol act as a negative regulator of this process. New frontiers for investigations include examining if ubiquinone contributes to the ROS scavenging and signaling roles that have been historically assigned to flavonols, as well as taking advantage of the metabolic node between flavonols and ubiquinone to manipulate oxidative stress resistance in crops.