Location: Location not imported yet.Title: Complete genome sequence of a representative vesicular stomatitis New Jersey virus strain (NJ03CPB) from an endemic region of southern Mexico
|VELAZQUEZ-SALINAS, LAURO - Autonomous National University Of Mexico|
Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/29/2019
Publication Date: 6/20/2019
Citation: Velazquez-Salinas, L., Pauszek, S.J., Rodriguez, L.L. 2019. Complete genome sequence of a representative vesicular stomatitis New Jersey virus strain (NJ03CPB) from an endemic region of southern Mexico. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.00499-19.
Interpretive Summary: Vesicular stomatitis (VS) is caused by vesicular stomatitis virus (VSV), an infectious agent belonging to the Rhabdoviridae family and the genus vesiculovirus, where vesicular stomatitis Indiana virus (VSIV) and VSNJV are the two main serotypes. The negative sense, single stranded RNA genome of VSV is about 11 kb, and encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L). VS is confined to the Americas, where VSNJV is the serotype responsible for the majority of the clinical cases reported annually in livestock. In Mexico, VSV is endemic in the southern states of Chiapas, Tabasco and Veracruz, where multiple phylogenetic analysis have shown the great genetic diversity associated with the concurrent circulation of multiple lineages. A relevant aspect of these endemic lineages is that some of them may become the precursors of the epidemic lineages responsible for sporadic outbreaks in the United Sates. Understanding the molecular and biological basis leading to the evolution of these epidemic lineages is vital to decipher the viral factors favoring the emergence of VS in the United States. Recent reports showing different virulence levels between endemic and epidemic VSNJV strains suggest that intrinsic viral factors might influence in part the emergence of these outbreaks. However, many questions remain regarding the specific sites in the genome playing a role in the emergence of epidemic phenotypes. In this context, the availability of the VSNJV endemic strain NJ03CPB increases the limited number of viral sequences from Mexico in public databases and will support future genetic analyses.
Technical Abstract: We report the full-genome sequence of a vesicular stomatitis New Jersey virus (VSNJV) strain obtained from lesion epithelium of a naturally infected cow in Chiapas, Mexico. This genome is a representative from the endemic zone of Mexico, a region of high genetic diversity.