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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Meat Safety & Quality Research » Research » Publications at this Location » Publication #358116

Research Project: Genomic and Metagenomic Differences in Foodborne Pathogens and Determination of Ecological Niches and Reservoirs

Location: Meat Safety & Quality Research

Title: Complete closed genome sequences of three Salmonella enterica subsp. enterica Serovar Dublin strains isolated from cattle at harvest

Author
item Harhay, Dayna
item Smith, Timothy - Tim
item Harhay, Gregory
item LONERAGAN, GUY - Texas Tech University
item WEBB, HATTIE - Centers For Disease Control And Prevention (CDCP) - United States
item BUGAREL, MARIE - Texas Tech University
item HALEY, BRADD - Environmental Microbial
item KIM, SEON - Environmental Microbial
item VAN KESSEL, JO ANN - Environmental Microbial

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/29/2018
Publication Date: 11/29/2018
Citation: Harhay, D.M., Smith, T.P.L., Harhay, G.P., Loneragan, G.H., Webb, H.E., Bugarel, M., Haley, B.J., Kim, S.W., Van Kessel, J.S. 2018. Complete closed genome sequences of three Salmonella enterica subsp. enterica Serovar Dublin strains isolated from cattle at harvest. Microbiology Resource Announcements. 7:e01334-18. https://doi.org/10.1128/MRA.01334-18.
DOI: https://doi.org/10.1128/MRA.01334-18

Interpretive Summary: Salmonella enterica are a leading cause of enterocolitis for humans and animals. While Salmonella infections are usually self-limiting, more severe infections can occur in susceptible populations (infants, elderly, immunocompromised individuals) and, when caused by drug-resistant Salmonella, treatment options are limited. Dublin are noted as a cattle-adapted Salmonella serotype, but they can cause disease in humans. A recent report on the epidemiology of S. Dublin demonstrates an increasing trend towards multidrug resistance in strains isolated from humans in the U.S. from 1968 - 2013, and that infections caused by this serotype are more likely to be invasive than infections caused by other common Salmonella serotypes. However, the genetic determinants contributing to this invasive phenotype are not well understood. In order to facilitate comparative genomics studies examining the virulence traits and drug resistance determinants of this serotype, we present the complete closed genome and plasmid sequences for three multi-drug resistant (MDR) S. Dublin strains isolated from cattle at harvest.

Technical Abstract: Salmonella enterica serovar Dublin is a host-adapted pathogen for cattle that can cause invasive disease in humans. To facilitate genomic comparisons characterizing virulence determinants of this pathogen, we present the complete genome sequences of three S. Dublin strains isolated from bovine sources at harvest.