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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Food Safety and Intervention Technologies Research » Research » Publications at this Location » Publication #349930

Research Project: The Role of Genotype in the Development and Validation of Growth Models and Intervention Technologies for Pathogenic Non-Shiga Toxigenic Escherichia coli Found in Foods

Location: Food Safety and Intervention Technologies Research

Title: Draft genome sequences of four uropathogenic escherichia coli 04:H5 isolates (ATCC 700414,700415,700416 and 700417)

item XU, AIXIA - Oak Ridge Institute For Science And Education (ORISE)
item Hertrich, Sarah
item Needleman, David
item Sheen, Shiowshuh - Allen
item Sommers, Christopher

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/21/2018
Publication Date: 3/15/2018
Citation: Xu, A., Hertrich, S.M., Needleman, D.S., Sheen, S., Sommers, C.H. 2018. Draft genome sequences of four uropathogenic escherichia coli 04:H5 isolates (ATCC 700414,700415,700416 and 700417). Genome Announcements. 6(11):e00134-18.

Interpretive Summary: Uropathogenic Escherichia coli (UPEC) are common contaminants in foods. Once ingested UPEC are able to colonize the gastrointestinal (GI) tract. Once in the GI tract they can infect ulcers in the GI tract (ulcerative colitis), escape, and eventually cause sepsis (blood poisoning). In addition, the UPEC can cause urinary tract infections, especially in women, when UPEC contaminated feces are accidentally transferred from the anus to the urethra. Genomics is now considered an integral part of microbial risk assessments for food safety. In this study we report the genomic DNA sequence of four clinical UPEC isolates which includes important characteristics such as their virulence factors and antibiotic resistances. This study data will allow improved risk assessments which will provide safer foods for consumers.

Technical Abstract: Uropathogenic Escherichia coli O4: H5 isolates ATCC 700414, 700415, 700416, and 700417 were recovered from women with first-time urinary tract infections. Here, we report the draft genome sequences for these four E. coli isolates, which are currently being used to validate food safety processing technologies.