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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Meat Safety & Quality Research » Research » Publications at this Location » Publication #332308

Research Project: Genomic and Metagenomic Differences in Foodborne Pathogens and Determination of Ecological Niches and Reservoirs

Location: Meat Safety & Quality Research

Title: Complete, closed genome sequences of 10 Salmonella enterica subsp. enterica serovar Typhimurium strains isolated from human and bovine sources

Author
item Nguyen, Scott
item Harhay, Dayna
item Bono, James - Jim
item Smith, Timothy - Tim
item Fields, Patricia - Centers For Disease Control And Prevention (CDCP) - United States
item Dinsmore, Blake - Centers For Disease Control And Prevention (CDCP) - United States
item Santovenia, Monica - Centers For Disease Control And Prevention (CDCP) - United States
item Kelley, Christy
item Wang, Rong
item Bosilevac, Joseph - Mick
item Harhay, Gregory

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/12/2016
Publication Date: 11/3/2016
Publication URL: http://handle.nal.usda.gov/10113/63295
Citation: Nguyen, S.V., Harhay, D.M., Bono, J.L., Smith, T.P.L., Fields, P.I., Dinsmore, B.A., Santovenia, M., Kelley, C.M., Wang, R., Bosilevac, J.M., Harhay, G.P. 2016. Complete, closed genome sequences of 10 Salmonella enterica subsp. enterica serovar Typhimurium strains isolated from human and bovine sources. Genome Announcements. 4(6):e01212-16. doi:10.1128/genomeA.01212-16.

Interpretive Summary: Non-typhoidal Salmonella enterica are a leading cause of foodborne illness in the U.S. and around the world. Of the greater than 2500 types of Salmonella enterica, serovar Typhimurium is consistently ranked as one of the two leading serovars attributed to salmonellosis, resulting in more than 6000 cases of reported illness each year. The decreasing cost of bacterial whole genome sequencing (WGS) is resulting in a wealth of sequence data of bacterial pathogens. WGS of Salmonella enterica strains is revealing the genetic diversity present in the “family tree” of this group of pathogens. These data have the potential to increase our understanding of what makes Salmonella Typhimurium such a successful pathogen, as well as provide information needed to differentiate members of one branch of the family tree from another. In order to increase our understanding of the genetic diversity of Salmonella Typhimurium associated with cattle and beef, we present here the complete, closed reference genome sequence data for ten Salmonella Typhimurium strains isolated from cattle or human sources.

Technical Abstract: Salmonella enterica are a leading cause of enterocolitis for humans and animals. S. enterica serovar Typhimurium infects a broad range of hosts. To facilitate genomic comparisons among isolates from different sources, we present the complete genome sequences of ten S. Typhimurium strains, five each isolated from human or bovine sources.