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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #328144

Research Project: ENHANCING GENETIC MERIT OF RUMINANTS THROUGH GENOME SELECTION AND ANALYSIS

Location: Animal Genomics and Improvement Laboratory

Title: Calculation of genomic predicted transmitting abilities for bovine respiratory disease complex in Holsteins

Author
item Van Tassell, Curtis - Curt
item Spangler, Gordon
item Bickhart, Derek
item Wiggans, George
item Cole, John
item TAYLOR, JEREMY - University Of Missouri
item NEIBERGS, HOLLY - Washington State University
item SEABURY, CHRIS - Texas A&M University
item VAN EENENNAAM, ALISON - University Of California
item WOMACK, JAMES - Texas A&M University
item BRD CONSORTIUM - Collaborator

Submitted to: Journal of Dairy Science
Publication Type: Abstract Only
Publication Acceptance Date: 4/21/2016
Publication Date: 7/9/2016
Citation: Van Tassell, C.P., Spangler, G.L., Bickhart, D.M., Wiggans, G.R., Cole, J.B., Taylor, J.F., Neibergs, H.L., Seabury, C., Van Eenennaam, A.L., Womack, J.E., Brd Consortium 2016. Calculation of genomic predicted transmitting abilities for bovine respiratory disease complex in Holsteins. Journal of Dairy Science. 99(E-Suppl. 1)/Journal of Animal Science. 94(E-Suppl. 5):133(abstr. 0288).

Interpretive Summary:

Technical Abstract: Bovine Respiratory Disease Complex is a disease that is very costly to the dairy industry. Genomic selection may be an effective tool to improve host resistance to the pathogens that cause this disease. Use of genomic predicted transmitting abilities (GPTA) for selection has had a dramatic effect on rates of genetic improvement in Holsteins, particularly for lowly heritable traits. Data were collected on 2,682 calves located in California (n=1978) and New Mexico (n=705). DNA was extracted and animals were genotyped using the BovineHD BeadChip. A total of 22 individuals were excluded based on genotype call rate and breed designation other than Holstein. Of the remaining animals, 708 had unidentified sires, the remaining 1952 animals were the offspring of 578 sires which were identified by genotype matching. There were 38 bulls with at least 10 offspring, 343 with at least 2 progeny, and 235 bulls with a single offspring in the data set. A standardized scoring system considering animal body temperature, cough severity, nasal discharge, and eye discharge or ear scores was used to characterize the disease status of all calves according to the McGuirk classification system. Currently, GPTA are being calculated from these data using a heritability value of 0.20 which will be validated from the data. Estimated genetic marker effects will be compared to results from previous genome-wide association studies. This project was supported by Agriculture and Food Research Initiative Competitive Grant no. 2011-68004-30367 from the USDA National Institute of Food and Agriculture.