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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Meat Safety & Quality Research » Research » Publications at this Location » Publication #328076

Research Project: Genomic and Metagenomic Differences in Foodborne Pathogens and Determination of Ecological Niches and Reservoirs

Location: Meat Safety & Quality Research

Title: Complete and closed genome sequences of 10 Salmonella enterica subsp. enterica serovar Anatum isolated from human and bovine sources

Author
item Nguyen, Scott
item Harhay, Dayna
item Bono, James - Jim
item Smith, Timothy - Tim
item Fields, Patricia - Centers For Disease Control And Prevention (CDCP) - United States
item Dinsmore, Blake - Centers For Disease Control And Prevention (CDCP) - United States
item Santovenia, Monica - Centers For Disease Control And Prevention (CDCP) - United States
item Kelley, Christy
item Wang, Rong
item Bosilevac, Joseph - Mick
item Harhay, Gregory

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/28/2016
Publication Date: 6/2/2016
Publication URL: http://handle.nal.usda.gov/10113/62840
Citation: Nguyen, S.V., Harhay, D.M., Bono, J.L., Smith, T.P.L., Fields, P.I., Dinsmore, B.A., Santovenia, M., Kelley, C.M., Wang, R., Bosilevac, J.M., Harhay, G.P. 2016. Complete and closed genome sequences of 10 Salmonella enterica subsp. enterica serovar Anatum isolated from human and bovine sources. Genome Announcements. Vol. 4(3): e00447-16. doi: 10.1128/genomeA.00447-16.

Interpretive Summary: Salmonella enterica are an important group of bacteria that are commonly found in association with human infections and contamination with human food sources. As recent foodborne outbreaks associated with Salmonella draw public attention from news media and public health interests, there is a greater need to increase surveillance on this important pathogen. One potential avenue for surveillance is genetic testing based on genomic sequence data, however most sequenced Salmonella genomes that are publicly accessible are derived from human illnesses. With over two thousand different serovars, there is a dearth of genetic information for Salmonella isolates from nonhuman sources such as healthy cattle. As Salmonella can be found in the environment, presence of Salmonella does not indicate virulence especially in healthy cattle. There is a growing body of literature that suggests that not all Salmonella serovars are capable of causing symptoms in humans. As beef producers are under greater scrutiny to screen for bacterial contaminants, understanding genetic differences between Salmonella isolated from healthy cattle and from pathogenic human clinical cases will provide better tools to rapidly identify foodborne outbreaks, mitigate public health risks, and minimize livestock production costs with pathogenic Salmonella contamination.

Technical Abstract: Salmonella enterica is an important pathogen transmitted by numerous vectors. Genomic comparisons of Salmonella from disparate hosts have the potential to further our understanding of mechanisms underlying host specificities and virulence. Here, we present closed genome and plasmid sequences of 10 Salmonella enterica subsp. enterica serovar Anatum from bovine and human sources.