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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #323828

Title: Population-genetic properties of differentiated copy number variations in cattle

item Liu, Ge - George

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 11/12/2015
Publication Date: 11/12/2015
Citation: Liu, G. 2015. Population-genetic properties of differentiated copy number variations in cattle [abstract]. China Agriculture University, November 12, 2015, Beijing, China.

Interpretive Summary:

Technical Abstract: Copy number variations (CNVs) have been shown to be both common in mammals and important for understanding the relationship between genotype and phenotype. However, CNV differentiation, selection and its population genetic properties are not well understood across diverse populations. We performed a population genetics survey based on CNVs derived from both high-throughput sequencing and the BovineHD SNP array data. We generated high resolution results that show geographical patterns of variations and genome-wide admixture proportions within and among breeds. Similar to the previous SNP-based studies, our CNV-based results displayed a strong correlation of population structure and geographical location. We further identified 78 unique CNV regions under diversifying selection across three pairwise comparisons among European taurine, African taurine, and indicine groups. These CNV regions overlapped with genes involved in traits related to parasite resistance, immunity response, body size, fertility, and milk production. Our results revealed the overall CNV diversity among cattle populations and provided evidence for divergent selection for lineage-differentiated CNVs.