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Title: HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice

item HUNG, SHAO-CHING - Dow Chemical Company
item Yokoyama, Wallace - Wally
item KIM, HYUNSOOK - University Of California
item Bartley, Glenn
item ANDERSON, WILLIAM H - Dow Chemical Company
item ALBERTS, DAVID - Dow Chemical Company
item LANGHORST, MARSHA - Dow Chemical Company
item WILLIAMS, DAVID - Dow Chemical Company
item STOTT, WILLIAM - Dow Chemical Company
item TUROWSKI, MACIEJ - Dow Chemical Company

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/18/2012
Publication Date: 10/19/2012
Citation: Hung, S., Yokoyama, W.H., Kim, H., Bartley, G.E., Anderson, W.K., Alberts, D.R., Langhorst, M.L., Williams, D.M., Stott, W., Turowski, M. 2012. HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice. Journal of Agricultural and Food Chemistry. 60(44):11149-11156.

Interpretive Summary: We evaluated a new type of soluble dietary fiber. Unlike most natural fibers that have are neutral or have a negative electrical charge, cationic hydroxyethyl cellulose (CHEC) has a positive charge. We found that in fat fed obese hamsters, CHEC reduced weight gain and particularly abdominal adipose weight gain. CHEC also lowered plasma and liver cholesterol. These results suggest that CHEC may be useful in preventing obesity related chronic diseases.

Technical Abstract: Cationic hydroxyethyl cellulose (cHEC) , was fed to hamsters to determine if this new soluble fiber had an effect on hypercholesterolemia and dyslipidemia associated with cardiovascular disease. In this study, Golden Syrian hamsters were supplemented with 3-8% cHEC or microcrystalline cellulose (MCC; control) in diets containing 39% energy from fat for four weeks. Supplementation of cHEC in a high-fat diet led to significant weight gain reduction in hamsters. In addition, significant decreases in adipose and liver weights, concentrations of plasma total-, VLDL-, and LDL-cholesterol, and hepatic lipids were shown. No significant improvements in glucose and insulin levels were observed with cHEC, however, a significant increase in plasma adiponectin and a decrease in leptin were observed. Compared with controls, cHEC-fed hamsters had greater levels of mRNA for CYP7A1 (cytochrome P450 7A1; 2-fold of control; P < 0.05), CYP5.1 (lanosterol 14a-demethylase; 6-fold of control; P < 0.05), and LDLR (LDL receptor; 1.5-fold of control) in the liver. These findings suggest the possibility of the use of cHEC for cholesterol reduction and beneficial effects on the cardiovascular risk factors.