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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #281313
Title: Regulation of energy metabolism by the extracytoplasmic function (ECF) s factors of Arcobacter butzleri

Author
item MARTINEZ-MALAXETXEBA, IRATI - University Of Basque Country
item MUTTS, RUDY - Utrecht University
item Parker, Craig
item Miller, William - Bill
item Huynh, Steven
item GAASTRA, WILLIAM - Utrecht University
item VAN PUTTEN, JOS - Utrecht University
item FERNANDEZ-ASTORGA, AURORA - University Of Basque Country
item WOSTEN, MARC - Utrecht University

Submitted to: PLOS ONE
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/14/2012
Publication Date: 9/18/2012
Citation: Martinez-Malaxetxeba, I., Mutts, R., Parker, C., Miller, W.G., Huynh, S., Gaastra, W., Van Putten, J.P., Fernandez-Astorga, A., Wosten, M.M. 2012. Regulation of energy metabolism by the extracytoplasmic function (ECF) s factors of Arcobacter butzleri. PLoS One. doi%2F10.1371%2Fjournal.pone.0044796.

Interpretive Summary: The extracytoplasmic function (ECF) s factors are important for bacterial adaptation to stressful environments. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of s/anti-s factors belonging to the ECF family. We identified the genes regulated by five out of the seven A. butzleri ECF s factors. Three of the ECF s factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF s factor indicating that the A. butzleri ECF s factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.

Technical Abstract: The extracytoplasmic function (ECF) s factors are fundamental for bacterial adaptation to distinct environments and for survival under different stress conditions. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of s/anti-s factors belonging to the ECF family. Here, we report the identification of the genes regulated by five out of the seven A. butzleri ECF s factors. Three of the ECF s factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF s factor indicating that the A. butzleri ECF s factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.