|LAWRENCE, PAUL - U.S. DEPARMENT OF HOMELAND SECURITY|
|Rieder, Aida - Elizabeth|
Submitted to: Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 2/13/2012
Publication Date: 1/1/2013
Citation: Lawrence, P., Rieder, A.E. 2013. Host and viral factors responsible for FMD pathogenesis. In: Topics in Foot and Mouth Disease. Scientific Developments and Technical Challenges in the Progresive Control of Foot-and-Mouth Diseasein South Asia, February 13-15, 2012, New Delhi, India. p. 8-23.
Technical Abstract: Foot-and-Mouth Disease Virus (FMDV), an Aphthovirus of the Picornaviridae, is one of the most intensely studied viruses yet the mechanisms by which it causes the highly transmissible disease FMD are largely unknown. A summary of current understanding of the molecular basis of FMDV interaction with the host will be discussed with special attention to three subjects: host interactions with (i) the viral RNA genome with its unique RNA secondary structures, each with a distinct role in the virus life cycle; (ii) the viral proteins that are translated from the positive-sense RNA genome; and (iii) the host proteins that are necessarily co-opted by the virus to fulfill its replication cycle, to produce one of the most contagious diseases known of animals and man.