Research Project: Reducing the Development and Severity of Allergy to Peanuts and Tree Nuts

Location: Food Processing and Sensory Quality Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Stress regulatory capabilities discovered in late embryogenesis abundant (LEA) proteins expressed during pecan (Carya illinoinensis) kernel development - (Peer Reviewed Journal)
Pulicherla, S., Clermont, K., Prestenburg, E.C., Mattison, C.P., Randall, J.J. 2025. Stress regulatory capabilities discovered in late embryogenesis abundant (LEA) proteins expressed during pecan (Carya illinoinensis) kernel development. BMC Genomics. https://doi.org/10.1186/s12864-025-12040-8.

Separation of intact cashew nut proteins by reversed-phase liquid chromatography for improved allergen resolution - (Peer Reviewed Journal)
Blackwell, D.L., Mcbride, J.K., Dupre, R.A., Priddy, D.M. 2025. Separation of intact cashew nut proteins by reversed-phase liquid chromatography for improved allergen resolution. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5c05463.

Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics - (Peer Reviewed Journal)
Swientoniewski, L., Rambo, I.M., Nesbit, J.B., Cheng, H., Gipson, S.A., Jones, S.M., Dreskin, S.C., Mustafa, S.S., Mueller, G.A., Maleki, S.J., Smith, S.A., Doan, D.T., Kulis, M.D., Rivers, A.R., Foo, A.C. 2025. Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics. Frontiers in Allergy. https://doi.org/10.3389/falgy.2025.1648262.

Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nuts allergens - (Peer Reviewed Journal)
Kabasser, S., Kamath, .T., Eber, E., Podzhilkova, A., Lupinek, C., Hemmer, W., Bublin, ., Croote, D., Maleki, S.J., Breiteneder, H., Hoffman-Sommergruber, K., Radauer, C., Bublin, M. 2025. Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nuts allergens.. Allergology International. https://doi.org/10.1016/j.alit.2025.05.007.

Purification and epitope mapping of Jug r 4, a major walnut allergen - (Peer Reviewed Journal)
Gipson, S.A., Swientoniewski, L.T., Rogers, S.I., Mustafa, S.S., Dreskin, S.C., Teuber, S.S., Cheng, H., Maleki, S.J. 2025. Purification and epitope mapping of Jug r 4, a major walnut allergen. Allergies. https://doi.org/10.3390/allergies5010008.

Heating differentiates pecan allergen stability: Car i 4 is more heat labile than Car i 1 and Car i 2 - (Peer Reviewed Journal)
Brown, C.N., Dupre, R.A., Ebmeier, C.C., Patil, S.L., Smith, B., Mattison, C.P. 2025. Heating differentiates pecan allergen stability: Car i 4 is more heat labile than Car i 1 and Car i 2. Food Science and Nutrition. https://doi.org/10.1002/fsn3.4747.

Phenylglyoxal modification of purified Ana o 3: characterizing changes in protein solubility, structure, and antibody recognition - (Abstract Only)

Responses of late embryogenesis abundant (LEA) genes reveal the potential of stress resilience in pecans - (Abstract Only)

Mitigating food protein allergy with biopolymers, bioactive compounds, and enzymes - (Review Article)
Sabaghi, M., Maleki, S.J. 2024. Mitigating food protein allergy with biopolymers, bioactive compounds, and enzymes. Allergies. https://doi.org/10.3390/allergies4040016.

Cottonseed vicilin proteins: potential allergen risk and source of bioactive peptides. - (Peer Reviewed Journal)
Vuong, T.T., Dupre, R.A., He, Z., Minkiewicz, P., Darewicz, M., Mattison, C.P. 2025. Glandless cottonseed C72 and GC72 vicilins cross-react with peanut and tree nut allergic IgE. ACS Food Science and Technology. https://doi.org/10.1021/acsfoodscitech.4c00577.

Enhancing Peanut and Tree Nut Allergy Diagnostics Using Linear and Conformational IgE Epitopes of Vicilin-Buried Peptides - (Abstract Only)

Murine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens - (Peer Reviewed Journal)
Musa, I., Ardalani, F., Yang, N., Maleki, S.J., Li, X. 2025. Murine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2024.1497368.

Diagnosis of Nut Allergy: The Role of Cross-Reactivity - (Abstract Only)

Food Processing, Allergenic Potential, and Possibilities for Immunotherapy - (Abstract Only)

Proteomic characterization of peanut flour fermented by rhizopus oryzae - (Peer Reviewed Journal)
Mattison, C.P., Dupre, R.A., Clermont, K., Gibbons, J.D., Yu, J. 2024. Proteomic characterization of peanut flour fermented by rhizopus oryzae. Heliyon. https://doi.org/10.1016/j.heliyon.2024.e34793.

Unraveling the role of LEA(Late embryogenesis abundant) genes in pecan stress resilience - (Abstract Only)

Modification of purified Ana o 3 with phenylglyoxal disrupts antibody binding - (Abstract Only)

Proteomic analysis of rhizopus oryzae fermented peanut allergens - (Abstract Only)

IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy - (Peer Reviewed Journal)
Rambo, I., Kronfel, C.M., Rivers, A.R., Swientoniewski, L., Mcbride, J.K., Cheng, H., Simon, R.J., Ryan, R., Tilles, S., Nesbit, J.B., Kulis, M.D., Hurlburt, B.K., Maleki, S.J. 2023. IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy. Frontiers in Allergy. 4: Article 1279290. https://doi.org/10.3389/falgy.2023.1279290.

Proteomic analysis of pecan (Carya illinoinensis) nut development - (Peer Reviewed Journal)
Clermont, K., Graham, C., Lloyd, S.W., Grimm, C.C., Randall, J., Mattison, C.P. 2023. Proteomic analysis of pecan (Carya illinoinensis) nut development. Foods. 12:866. https://doi.org/10.3390/foods12040866.

Cross-serological reaction of glandless cottonseed proteins to peanut and tree nut allergic IgE - (Peer Reviewed Journal)
Mattison, C.P., He, Z., Zhang, D., Dupre, R., Lloyd, S.W. 2023. Cross-serological reaction of glandless cottonseed proteins to peanut and tree nut allergic IgE. Molecules. 28(4):1587. https://doi.org/10.3390/molecules28041587.

Structure, immunogenicity, and IgE cross-reactivity among cashew, pistachio, and peanut vicilin-buried peptides - (Peer Reviewed Journal)
Foo, A., Nesbit, J.B., Gipson, S., Cheng, H., Hurlburt, B.K., Kulis, M.D., Kim, E.H., Dreskin, S., Maleki, S.J., Mueller, G. 2022. Structure, immunogenicity, and IgE cross-reactivity among cashew, pistachio, and peanut vicilin-buried peptides. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.1c07225.

IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US - (Peer Reviewed Journal)
Kronfel, C., Cheng, H., Mcbride, J.K., Krouse, R., Burns, P., Cabanillas, B., Crespo, J.F., Simon, R.J., Robert, R., Maleki, S.J., Hurlburt, B.K. 2023. IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US. Frontiers in Allergy. https://doi.org/10.3389/falgy.2022.1090114.

Changes in IgE and IgG4 epitopes of the peanut allergens following peanut oral immunotherapy - (Abstract Only)
Rambo, I.M., Rivers, A.R., Mcbride, J.K., Swientoniewski, L., Cheng, H., Simon, R.J., Robert, R., Nesbit, J.B., Maleki, S.J. 2023. Changes in IgE and IgG4 epitopes of the peanut allergens following peanut oral immunotherapy. American Academy of Allergy Asthma and Immunology. 151,p. AB33. https://doi.org/10.1016/j.jaci.2022.12.104.

Manufacturing processes of peanut (arachis hypogaea) allergen powder-dnfp - (Peer Reviewed Journal)
Leonard, S.A., Ogawa, Y., Jedrzejewski, P.T., Maleki, S.J., Chapman, M.D., Tiles, S.A., Du Toit, G., Mustafa, S., Vickery, B.P. 2022. Manufacturing processes of peanut (arachis hypogaea) allergen powder-dnfp. Frontiers in Allergy. 3. https://doi.org/10.3389/falgy.2022.1004056.

Targeting CD22 on Memory B cells to induce tolerance to peanut allergens - (Peer Reviewed Journal)
Hardy, L.C., Smeekens, J., Raghuwanshi, D., Sarkar, S., Dashkan, G.C., Rogers, S.I., Maleki, S.J., Burks, W.A., Paulson C, J.C., Macauley, M.S., Kulis, M.D. 2022. Targeting CD22 on Memory B cells to induce tolerance to peanut allergens. Journal of Allergy Clinical Immunology. 150(6):1476-1485. https://doi.org/10.1016/j.jaci.2022.06.022.

Quantitative in silico evaluation of allergenic proteins from Anacardium occidentale, Carya illinoinensis, Juglans regia, and Pistacia vera and their epitopes as precursors of bioactive peptides - (Peer Reviewed Journal)
Minkiewicz, P., Mattison, C.P., Darewicz, M. 2022. Quantitative in silico evaluation of allergenic proteins from Anacardium occidentale, Carya illinoinensis, Juglans regia, and Pistacia vera and their epitopes as precursors of bioactive peptides. Current Issues in Molecular Biology. 44(7): 3100-3117. https://doi.org/10.3390/cimb44070214.

Heating induces chemical modification and variable solubility of pecan allergens - (Abstract Only)

Cross-serological reaction of peanut and tree nut allergic IgE to glandless cottonseed proteins - (Abstract Only)

In silico modeling of peanut allergic IgE and docking to Ara h 2 - (Abstract Only)

Effect of high-moisture extrusion and addition of transglutaminase on major peanut allergens content extracted by three step sequential method - (Peer Reviewed Journal)
Faisal, S., Zhang, J., Meng, S., Shi, A., Li, L., Wang, Q., Maleki, S.J., Adhikari, B. 2022. Effect of high-moisture extrusion and addition of transglutaminase on major peanut allergens content extracted by three step sequential method. Food Chemistry. 385:132569. https://doi.org/10.1016/j.foodchem.2022.132569.

Structure, immunogenicity, and IgE cross-reactivity among walnut and peanut vicilin buried peptides - (Peer Reviewed Journal)
Foo, A.C.Y., Nesbit, J.B., Gipson, S.A.Y., Cheng, H., Buschel, P., Derose, E.F., Schein, C.H., Teuber, S.S., Hurlburt, B.K., Maleki, S.J., Mueller, G.A. 2022. Structure, immunogenicity, and IgE cross-reactivity among walnut and peanut vicilin buried peptides. Journal of Agricultural and Food Chemistry. 70(7):2389-2400. https://doi.org/10.1021/acs.jafc.1c07225.

Characterization of anti-ana o 3 monoclonal antibodies and their application in comparing brazilian cashew cultivars - (Peer Reviewed Journal)
Mattison, C.P., Vant-Hull, B., de Castro, A., Chial, H.J., Bren-Mattison, Y., Bechtel, P.J., de Brito, E.S. 2021. Characterization of anti-ana o 3 monoclonal antibodies and their application in comparing brazilian cashew cultivars. Antibodies. 10(4):46. https://doi.org/10.3390/antib10040046.

In Silico Modeling and Docking of SPECC1L Coiled Coil Domain with hMps1 Tetratricopeptide Repeat - (Abstract Only)

Four chromosome scale genomes and a pan-genome annotation to accelerate pecan tree breeding - (Peer Reviewed Journal)
Lovell, J.T., Bentley, N.B., Bhattarai, G., Jenkins, J.W., Sreedasyam, A., Alarcon, Y., Bock, C., Boston, L.B., Carlson, J., Cervantes, K., Clermont, K., Duke, S., Krom, N., Kubenka, K., Mamidi, S., Mattison, C.P., Monteros, M.J., Pisani, C., Plott, C., Rajasekar, S., Rhein, H.S., Rohla, C., Song, M., St. Hilaire, R., Shu, S., Wells, L., Webber, J., Heerema, R.J., Klein, P.E., Conner, P., Wang, X., Grauke, L.J., Grimwood, J., Schmutz, J., Randall, J.J. 2021. Four chromosome scale genomes and a pan-genome annotation to accelerate pecan tree breeding. Nature Communications. 12:4125. https://doi.org/10.1038/s41467-021-24328-w.

Allergens and their associated small molecule ligands - their dual role in sensitization - (Peer Reviewed Journal)
Chruszcz, M., Chew, F.T., Hoffmann-Sommergruber, K., Hurlburt, B.K., Mueller, G.A., Pomes, A., Rouvinen, J., Villalba, M., Wohrl, B.M., Breiteneder, H. 2021. Allergens and their associated small molecule ligands - their dual role in sensitization. Allergy. 76:2367-2382. https://doi.org/10.1111/all.14861.

Adult peanut allergy: What we know and what we need to learn - (Peer Reviewed Journal)
Maleki, S.J., Teuber, S.S., Mustafa, S.S. 2021. Adult peanut allergy: What we know and what we need to learn. Journal of Allergy Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.03.031.

Peanut protein acts as a Th2 adjuvant by inducing expression of RALDH2 in human antigen-presenting cells in a TLR2-dependent manner - (Peer Reviewed Journal)
Ruiter, B., Smith, N.P., Flemming, E., Patil, S.U., Hurlburt, B.K., Maleki, S.J., Shreffler, W.G. 2021. Peanut protein acts as a Th2 adjuvant by inducing expression of RALDH2 in human antigen-presenting cells in a TLR2-dependent manner. Journal of Allergy Clinical Immunology. 148(1):182-194. https://doi.org/10.1016/j.jaci.2020.11.047.

Genetically engineered fusion of allergen and viral-like particle induces a more effective allergen-specific immune response than a combination of them - (Peer Reviewed Journal)
Zamani Sani, M., Bargahi, A., Momenzadeh, N., Dehghani, P., Vakili Moghadam, M., Maleki, S.J., Nabipour, I., Shirkani, A., Akhtari, J., Hesamizadeh, K., Heidari, S., Omrani, F., Akbarzadeh, S., Mohamadi, M. 2020. Genetically engineered fusion of allergen and viral-like particle induces a more effective allergen-specific immune response than a combination of them. Applied Microbiology and Biotechnology. 105:77-91. https://doi.org/10.1007/s00253-020-11012-0.

Allergenicity and food processing - (Popular Publication)
McHugh, T., Maleki, S.J. 2020. Allergenicity and food processing. Food Technology. 1020:77-79.

Cloning, expression, and immunological characterization of formosan subterranean termite (blattodea: rhinotermitidae) arginine kinase - (Peer Reviewed Journal)
Mattison, C.P., Tungtrongchitr, A., Tille, K.S., Cottone, C.B., Riegel, C. 2020. Cloning, expression, and immunological characterization of formosan subterranean termite (blattodea: rhinotermitidae) arginine kinase. Journal of Insect Science. Volume 20; Issue 4. https://doi.org/10.1093/jisesa/ieaa071.

Identification and assessment of the IgE epitopes of Ara h 1 and Jug r 2 leader sequences - (Abstract Only)
Nesbit, J.B., Cheng, H., Hurlburt, B.K., Maleki, S.J. 2018. Identification and assessment of the IgE epitopes of Ara h 1 and Jug r 2 leader sequences. American Academy of Allergy Asthma and Immunology. 141:2.

Identification and assessment of IgE epitopes of Ara h 1, Jug r 2, Ana o 1 and Pis v 3 leader sequences - (Abstract Only)