Skip to main content
ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Methods and Application of Food Composition Laboratory » Research » Research Project #436868

Research Project: USDA Dietary Supplement Ingredient Program

Location: Methods and Application of Food Composition Laboratory

Project Number: 8040-52000-068-040-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Jul 1, 2019
End Date: Sep 30, 2023

The Dietary Supplement Ingredient Database (DSID) (https:/ /; (U.S. Department of Agriculture, 2017) currently provides nationally representative supplement composition data for adult, children’s and prenatal MVM and individual fatty acids in omega-3 fatty acid DS, based on chemical analysis. All other dietary supplement databases contain label information only. In addition to the evaluation of vitamin and mineral levels in dietary supplements, the DSID is expanding to include supplements with other ingredients of interest, including catechins and caffeine in green tea dietary supplements, and curcuminoids in turmeric dietary supplements. Objective 1: Determine, evaluate, and expand knowledge about the composition of frequently consumed dietary supplements in the U.S. by collecting and compiling data and information on essential nutrients and emerging components of public health importance. This includes developing methods for sampling new dietary supplement product types, statistically evaluating analytical results to portray representative estimates, and improving the value of the Dietary Supplement Ingredient Database by utilizing new technologies to generate novel datasets. dietary supplement product types, statistically.

Several types of studies are planned, including ongoing national studies and new pilot and national studies. NDL will design and carry out research to analytically determine the ingredient composition of representative dietary supplements, including essential nutrients and bioactive components. NDL will identify laboratories for sample analysis and evaluate data quality. Results will be statistically evaluated and made publicly available through the DSID. On-going DSID Studies: 1) Omega-3 fatty acid national study: scientifically evaluate the relationships between labeled and analytical levels of omega- 3 fatty acids in representative dietary supplements, including fish oil, plant oil and fish/ plant oil blends. Release mean results and variability information from this study in DSID-3. 2) Over-the-Counter (OTC) prenatal MVM national study: scientifically evaluate the relationship between label and analytical values and assess the variability for up to 22 vitamins and minerals in OTC prenatal MVM. Release mean results and variability information from this study in DSID-3. 3) Adult MVM monitoring study: systematically evaluate the statistical relationships between label and analytical data since the first adult MVM study in a monitoring study of adult MVM, and release results in DSID-4. The information from this study will be used to plan the frequency and scope of updates to DSID for other MVM and possibly other supplement categories. Pilot Studies: 1) Green tea and flavonoid-containing dietary supplements (DS) study: methods of analysis will be evaluated by testing representative and top-selling products for prioritized ingredients of interest. 2) Calcium in DS and OTC antacids study: DS and OTC antacids, a major source of supplemental calcium intake in the U.S., will be assessed for their calcium and vitamin D content. National Studies: 1) Green tea DS and flavonoid-containing DS studies: obtain mean estimates for and measures of variability for analyzed catechins, caffeine, and for analyzed flavonoids (such as flavonols, flavones, flavanones, catechins, and anthocyanidins) in nationally representative botanical DS. 2) Calcium in DS and OTC antacids study: determine national estimates for ingredients in calcium-containing DS, a commonly reported supplement.