Research Project: Diet and Cardiovascular Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Associations of bone mineral density with lean mass, fat mass, and physical activity in young overweight and obese women - A feasibility study - (Peer Reviewed Journal)
Garvey, M.E., Shi, L., Lichtenstein, A.H., Must, A., Hayman, L.L., Crouter, S.E., Camhi, S.M. 2022. Associations of bone mineral density with lean mass, fat mass, and physical activity in young overweight and obese women - A feasibility study. International Journal of Exercise Science. 15(7):585-598.

Plasma metabolite profiles following consumption of animal protein and soybean-based diet in hypercholesterolemic postmenopausal women - (Peer Reviewed Journal)
Huang, N.K., Matthan, N., Matuszek, G.H., Lichtenstein, A.H. 2022. Plasma metabolite profiles following consumption of animal protein and soybean-based diet in hypercholesterolemic postmenopausal women. Metabolites. 12(3):209. https://doi.org/10.3390/metabo12030209.

Plasma metabolites associated with a protein-rich dietary pattern: Results from the OmniHeart trial - (Peer Reviewed Journal)
Kim, H., Lichtenstein, A.H., White, K., Wong, K.E., Miller Iii, E.R., Coresh, J., Appel, L.J., Rebholz, C.M. 2022. Plasma metabolites associated with a protein-rich dietary pattern: Results from the OmniHeart trial. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.202100890.

Associations between taste perception profiles and empirically derived dietary patterns: an exploratory analysis among older adults with metabolic syndrome - (Peer Reviewed Journal)
Gervis, J., Fernandez-Carrion, R., Chui, K.K., Ma, J., Coltell, O., Sorli, J.V., Asensio, E.M., Ortega-Azorin, C., Perez-Fidalgo, J., Portoles, O., Lichtenstein, A.H., Corella, D. 2021. Associations between taste perception profiles and empirically derived dietary patterns: an exploratory analysis among older adults with metabolic syndrome. Nutrients. 14(1):142. https://doi.org/10.3390/nu14010142.

2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association - (Review Article)
Lichtenstein, A.H., Appel, L.J., Vadiveloo, M., Hu, F.B., Kris-Etherton, P.M., Rebholz, C.M., Sacks, F.M., Thorndike, A.M., Van Horn, L., Wylie-Rosett, J. 2021. 2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association. Circulation. 144(23):e472-e487. https://doi.org/10.1161/CIR.0000000000001031.

The design and rationale of a multi-center randomized clinical trial comparing one avocado per day to usual diet: The Habitual Diet and Avocado Trial (HAT) - (Peer Reviewed Journal)
Reboussin, D.M., Kris-Etherton, P.M., Lichtenstein, A.H., Li, Z., Sabate, J., Matthan, N., Petersen, K.S., Rajaram, S., Vitolins, M.Z., Ford, N. 2021. The design and rationale of a multi-center randomized clinical trial comparing one avocado per day to usual diet: The Habitual Diet and Avocado Trial (HAT). Contemporary Clinical Trials. 110: 106565. https://doi.org/10.1016/j.cct.2021.106565.

Serum non-esterified fatty acids, carotid artery intima-media thickness and flow-mediated dilation in older adults: The Cardiovascular Health Study (CHS) - (Peer Reviewed Journal)
Huang, N.K., Buzkova, P., Matthan, N., Djousse, L., Kizer, J.R., Mukamal, K., Polak, J.F., Lichtenstein, A.H. 2021. Serum non-esterified fatty acids, carotid artery intima-media thickness and flow-mediated dilation in older adults: The Cardiovascular Health Study (CHS). Nutrients. 13(9):3052. https://doi.org/10.3390/nu13093052.

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society - (Peer Reviewed Journal)
Ginsberg, H.N., Packard, C., Chapman, M.J., Boren, J., Aguilar-Salinas, C.A., Averna, M., Ference, B.A., Gaudet, D., Hegele, R.A., Kersten, S., Lewis, G.F., Lichtenstein, A.H., Moulin, P., Nordestgaard, B.G., Remeley, A.T., Staels, B., Stroes, E.S., Taskinen, M., Tokgozoglu, L.S., Tybjaerg-Hansen, A., Stock, J.K., Catapano, A.L. 2021. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. European Heart Journal. 42(47):4791-4806. https://doi.org/10.1093/eurheartj/ehab551.

Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation - (Peer Reviewed Journal)
Chang, W., So, J., Lamon-Fava, S. 2021. Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation. Scientific Reports. 11:16324. https://doi.org/10.1038/s41598-021-95590-7.

Strategies for promotion of a healthy lifestyle in clinical settings: Pillars of ideal cardiovascular health: A science advisory from the American Heart Association - (Review Article)
Kris-Etherton, P., Petersen, K., Despres, J., Anderson, C.A., Deedwania, P., Furie, K.L., Lear, S., Lichtenstein, A.H., Lobelo, F., Morris, P., Sacks, F.M., Ma, J. 2021. Strategies for promotion of a healthy lifestyle in clinical settings: Pillars of ideal cardiovascular health: A science advisory from the American Heart Association. Circulation. 144(24):e495-e514. https://doi.org/10.1161/CIR.0000000000001018.

Spillover effects of a family-based childhood obesity intervention on parental nutrient biomarkers and cardiometabolic risk factors - (Abstract Only)
Matthan, N., Barger, K., Wylie-Rossett, J., Xue, X., Gao, Q., Groisman-Perelstein, A.E., Diamantis, P.M., Ginsberg, M., Mossavar-Rahmani, Y., Lichtenstein, A.H. 2021. Spillover effects of a family-based childhood obesity intervention on parental nutrient biomarkers and cardiometabolic risk factors. Current Developments in Nutrition. 5:1233. https://doi.org/10.1093/cdn/nzab055_043.

Serum fasting non-esterified fatty acids and carotid artery intima-media thickness in older adults: the Cardiovascular Health Study - (Abstract Only)
Huang, N.K., Buzkova, P., Matthan, N., Djousse, L., Kizer, J.R., Mukamal, K.J., Polak, J.F., Lichtenstein, A.H. 2021. Serum fasting non-esterified fatty acids and carotid artery intima-media thickness in older adults: the Cardiovascular Health Study. Current Developments in Nutrition. 5:1043. https://doi.org/10.1093/cdn/nzab053_036.

Carotenoid-rich brain nutrient pattern is positively correlated with higher cognition and lower depression in the oldest old with no dementia - (Peer Reviewed Journal)
Tanprasertsuk, J., Scott, T.M., Barbey, A.K., Barger, K., Wang, X., Johnson, M., Poon, L.W., Vishwanathan, R., Matthan, N., Lichtenstein, A.H., Ferland, G., Johnson, E.J. 2021. Carotenoid-rich brain nutrient pattern is positively correlated with higher cognition and lower depression in the oldest old with no dementia. Frontiers in Nutrition. 8:704691. https://doi.org/10.3389/fnut.2021.704691.

Taste perception profiles are associated with patterns of adherence to a Mediterranean diet among older adults with metabolic syndrome - (Abstract Only)
Gervis, J., Chui, K., Ma, J., Coltell, O., Fernandez-Carrion, R., Sorli, J.V., Barragan, R., Gonzalez, J.I., Gimenez-Alba, I.M., Martinez-Lacruz, R., Guillem-Saiz, P., Pascual-Catello, E.C., Portoles, O., Ortega0-Azorin, C., Corella, D., Lichtensetin, A.H. 2021. Taste perception profiles are associated with patterns of adherence to a Mediterranean diet among older adults with metabolic syndrome [abstract]. Circulation. 143:AMP04. https://doi.org/10.1161/circ.143.suppl_1.MP04.

Serum non-esterified fatty acid levels and hip fracture risk: The Cardiovascular Health Study - (Peer Reviewed Journal)
Barzilay, J.I., Buzkova, P., Djousse, L., Ix, J.H., Kizer, J.R., Cauley, J.A., Matthan, N., Lichtenstein, A.H., Mukamal, K.J. 2021. Serum non-esterified fatty acid levels and hip fracture risk: The Cardiovascular Health Study. Osteoporosis International. https://doi.org/10.1007/s00198-021-05897-4.

Alcohol consumption and risk of cardiovascular disease, cancer and mortality: a prospective cohort study - (Peer Reviewed Journal)
Zhang, X., Liu, Y., Li, S., Lichtenstein, A.H., Chen, S., Na, M., Veldheer, S., Xing, A., Wang, Y., Wu, S., Gao, X. 2021. Alcohol consumption and risk of cardiovascular disease, cancer and mortality: a prospective cohort study. Nutrition Journal. 20:13. https://doi.org/10.1186/s12937-021-00671-y.

Individual non-esterified fatty acids and incident atrial fibrillation late in life - (Peer Reviewed Journal)
Pellegrini, C.N., Buzkova, P., Lichtenstein, A.H., Matthan, N.R., Ix, J.H., Siscovick, D.S., Heckbert, S.R., Tracy, R.P., Mukamal, K.J., Djousse, L., Kizer, J.R. 2021. Individual non-esterified fatty acids and incident atrial fibrillation late in life. Heart. heartjnl-2020-317929. https://doi.org/10.1136/heartjnl-2020-317929.

Urine metabolites associated with the Dietary Approaches to Stop Hypertension (DASH) diet: results from the DASH-sodium trial - (Peer Reviewed Journal)
Kim, H., Lichtenstein, A.H., Wong, K.E., Appel, L.J., Coresh, J., Rebholz, C.M. 2020. Urine metabolites associated with the Dietary Approaches to Stop Hypertension (DASH) diet: results from the DASH-sodium trial. Molecular Nutrition and Food Research. 65(3):2000695. https://doi.org/10.1002/mnfr.202000695.

Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation - (Peer Reviewed Journal)
Lamon-Fava, S., So, J., Mischoulon, D., Ziegler, T.R., Dunlop, B.W., Kinkead, B., Schettler, P.J., Nierenberg, A.A., Felger, J.C., Rao Maddipati, K., Fava, M., Rapaport, M.H. 2020. Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation. Prostaglandins Leukotrienes and Essential Fatty Acids. https://doi.org/10.1016/j.plefa.2020.102219.

EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study - (Peer Reviewed Journal)
So, J., Wu, D., Lichtenstein, A.H., Tai, A.K., Matthan, N.R., Rao Maddipati, K., Lamon-Fava, S. 2020. EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study. Atherosclerosis. 316:90-98. https://doi.org/10.1016/j.atherosclerosis.2020.11.018.

Impact of physical activity, diet quality and stress on cardiometabolic health in school employees - (Peer Reviewed Journal)
Schultz, N.S., Chui, K.K., Economos, C.D., Lichtenstein, A.H., Volpe, S.L., Sacheck, J.M. 2020. Impact of physical activity, diet quality and stress on cardiometabolic health in school employees. Preventive Medicine Reports. 20:101243. https://doi.org/10.1016/j.pmedr.2020.101243.

Evidence-based policy making for public health interventions in cardiovascular diseases: formally assessing the feasibility of clinical trials - (Peer Reviewed Journal)
Foti, K., Foraker, R.E., Martyn-Nemeth, P., Anderson, C.A., Cook, N.R., Lichtenstein, A.H., De Ferranti, S.D., Rohm Young, D., Hivert, M., Ross, R., Deedwania, P., Whitsel, L.P., Appel, L.J. 2020. Evidence-based policy making for public health interventions in cardiovascular diseases: formally assessing the feasibility of clinical trials. Circulation: Cardiovascular Quality and Outcomes. 13:e006378. https://doi.org/10.1161/CIRCOUTCOMES.119.006378.

Rapid diet assessment screening tools for cardiovascular disease risk reduction across healthcare settings: A scientific statement from the American Heart Association - (Review Article)
Vadiveloo, M., Lichtenstein, A.H., Anderson, C.A., Aspry, K., Foraker, R., Griggs, S., Hayman, L.L., Johnston, E., Stone, N.J., Thorndike, A.N. 2020. Rapid diet assessment screening tools for cardiovascular disease risk reduction across healthcare settings: A scientific statement from the American Heart Association. Circulation: Cardiovascular Quality and Outcomes. 13(9):702-715. https://doi.org/10.1161/HCQ.0000000000000094.

Perspective: Guidelines needed for the conduct of human nutrition randomized controlled trials - (Review Article)
Weaver, C.M., Lichtenstein, A.H., Kris-Etherton, P.M. 2020. Perspective: Guidelines needed for the conduct of human nutrition randomized controlled trials. Advances in Nutrition. 12(1):1-3. https://doi.org/10.1093/advances/nmaa083.

Supplementation with seabuckthorn oil augmented in 16:1n-7t increases serum trans-palmitoleic acid in metabolically healthy adults: a randomized crossover dose-escalation study - (Peer Reviewed Journal)
Huang, N.K., Matthan, N.R., Galluccio, J.M., Shi, P., Lichtenstein, A.H., Mozaffarian, D. 2020. Supplementation with seabuckthorn oil augmented in 16:1n-7t increases serum trans-palmitoleic acid in metabolically healthy adults: a randomized crossover dose-escalation study. Journal of Nutrition. https://doi.org/10.1093/jn/nxaa060.

EPA and DHA have differential effects on cholesterol ester transfer protein and lipoprotein lipase activities following plasma triglycerides lowering - (Abstract Only)
So, J., Asztalos, B.F., Horvth, K.V., Lichtenstein, A.H., Lamon-Fava, S. 2020. EPA and DHA have differential effects on cholesterol ester transfer protein and lipoprotein lipase activities following plasma triglycerides lowering. Current Developments in Nutrition. 4(Suppl_2):662. https://doi.org/10.1093/cdn/nzaa049_055.

Plasma metabolomic signatures of the American Heart Association diet score: findings from the Boston Puerto Rican Health Study - (Abstract Only)
Haslam, D., Li, J., Liang, L., Clish, C., Lichtenstein, A.H., Lai, C., Ordovas, J.M., Manson, J.E., Wittenbecher, C., Hu, F.B., Qi, Q., Tucker, K.L., Bhupathiraju, S.N. 2020. Plasma metabolomic signatures of the American Heart Association diet score: findings from the Boston Puerto Rican Health Study. Circulation. 141:Abstract 52. https://doi.org/10.1161/circ.141.suppl_1.52.

Serum non-esterified fatty acids and risk of incident stroke in older adults: the cardiovascular health study - (Abstract Only)
Huang, N.K., Matthan, N.R., Biggs, M.L., Longstreth, Jr., W.T., Siscovick, D., Djousse, L., Mukamal, K.J., Lichtenstein, A.H. 2020. Serum non-esterified fatty acids and risk of incident stroke in older adults: the cardiovascular health study [abstract]. Circulation. 141:Abstract 560. https://doi.org/10.1161/circ.141.suppl_1.P560.

Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination. Current Developments in Nutrition. 4(Suppl_2):1182. https://doi.org/10.1093/cdn/nzaa056_029.

Serum non-esterified fatty acids and risk of incident stroke in older adults: the Cardiovascular Health Study - (Abstract Only)
Huang, N.K., Matthan, N.R., Biggs, M.L., Longstreth, Jr., W.T., Siscovick, D., Djousse, L., Mukamal, K.J., Lichtenstein, A.H. 2020. Serum non-esterified fatty acids and risk of incident stroke in older adults: the Cardiovascular Health Study. Current Developments in Nutrition. 4(Suppl_2):1416. https://doi.org/10.1093/cdn/nzaa061_044.

Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs. Current Developments in Nutrition. 4(Suppl_2):577. https://doi.org/10.1093/cdn/nzaa046_077.

Dose-dependent effects of EPA supplementation on plasma specialized pro-resolving mediators in major depressive disorder patients with chronic inflammation - (Abstract Only)
So, J., Lamon-Fava, S., Fava, M., Mischoulon, D., Nierenberg, A., Dunlop, B., Schettler, P., Kinkead, B., Ziegler, T.R., Rapaport, M.H. 2020. Dose-dependent effects of EPA supplementation on plasma specialized pro-resolving mediators in major depressive disorder patients with chronic inflammation. Current Developments in Nutrition. 4(Suppl_2):1538. https://doi.org/10.1093/cdn/nzaa068_023.

Taste perception profiles and adiposity in older adults with metabolic syndrome - PREDIMED-Plus - (Abstract Only)
Gervis, J.E., Chui, K., Coltell, O., Corella, D., Lichtenstein, A.H. 2020. Taste perception profiles and adiposity in older adults with metabolic syndrome - PREDIMED-Plus. Current Developments in Nutrition. 4(Suppl_2):1635. https://doi.org/10.1093/cdn/nzaa063_033.

Higher bitter taste perception is associated with lower diabetes risk among older adults with metabolic syndrome - the PREDIMED-PLUS trial - (Abstract Only)
Gervis, J.E., Coltell, O., Sorli, J.V., Corella, D., Lichtenstein, A.H. 2020. Higher bitter taste perception is associated with lower diabetes risk among older adults with metabolic syndrome - the PREDIMED-PLUS trial. AHA Epi/Lifestyle. https://doi.org/10.1161/circ.141.suppl_1.P284.

Association of individual plasma non-esterifired fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study - (Abstract Only)
Pelligrini, C.N., Kizer, J.R., Buzkova, P., Matthan, N., Lichtenstein, A.H., Siscovick, D.S., Ix, J.H., Heckbert, S.R., Mukamal, K.J., Djousse, L. 2020. Association of individual plasma non-esterifired fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. American Journal of Cardiology. 75(11):Suppl_1. Abstract 1271-235. https://doi.org/10.1016/S0735-1097(20)31031-7.

Dietary sodium-let's focus on what we know and how to move forward - (Other)
Lichtenstein, A.H. 2019. Dietary sodium-let's focus on what we know and how to move forward. Nutrition Today. 54(6):245-247. https://doi.org/10.1097/01.NT.0000604480.64658.44.

The association of serum magnesium with chondrocalcinosis and osteoarthritis - (Abstract Only)
Misra, D., Sun, X., Nevitt, M., Lewis, C.E., Torner, J., Neogi, T., Lichtenstein, A.H., Matthan, N.R., Felson, D. 2019. The association of serum magnesium with chondrocalcinosis and osteoarthritis [abstract]. American College of Rheumatology/ARP Annual Meeting. Abstract No. 878.

Is there an association of serum LDL, HDL and total cholesterol with the development of knee osteoarthritis? - (Abstract Only)
Barlow, J.L., Sun, X., Nevitt, M.C., Torner, J., Lewis, C.E., Matthan, N., Lichtenstein, A.H., Felson, D. 2019. Is there an association of serum LDL, HDL and total cholesterol with the development of knee osteoarthritis? [abstract]. 2019 American College of Rheumatology and Association of Rheumatology Professionals [ACR/ARP] Annual Meeting. Abstract No. 2199.

The triglyceride paradox is related to lipoprotein size, visceral adiposity and stearoyl-CoA desaturase activity in black vs. white women - (Peer Reviewed Journal)
Chung, S.T., Cravalho, C.K., Meyers, A.G., Courville, A.B., Yang, S., Matthan, N.R., Mabundo, L., Sampson, M.L., Ouwerkerk, R., Gharib, A.M., Lichtenstein, A.H., Remaley, A.T., Sumner, A.E. 2019. The triglyceride paradox is related to lipoprotein size, visceral adiposity and stearoyl-CoA desaturase activity in black vs. white women. Circulation Research. 126(1):94-108. https://doi.org/10.1161/CIRCRESAHA.119.315701.

Association of trajectory of cardiovascular health score and incident cardiovascular disease - (Peer Reviewed Journal)
Wu, S., An, S., Li, W., Lichtenstein, A.H., Gao, J., Kris-Etherton, P.M., Wu, Y., Jin, C., Huang, S., Hu, F., Gao, X. 2019. Association of trajectory of cardiovascular health score and incident cardiovascular disease. JAMA Network Open. 2(5):e194758. https://doi.org/10.1001/jamanetworkopen.2019.4758.

Association between taste perception and adiposity in overweight or obese older subjects with metabolic syndrome and identification of novel taste-related genes - (Peer Reviewed Journal)
Coltell, O., Sorli, J.V., Asensio, E.M., Fernandez-Carrion, R., Barragan, R., Ortega-Azorin, C., Estruch, R., Gonzalez, J.I., Salas-Salvado, J., Lamon-Fava, S., Lichtenstein, A.H., Corella, D. 2019. Association between taste perception and adiposity in overweight or obese older subjects with metabolic syndrome and identification of novel taste-related genes. American Journal of Clinical Nutrition. 109(6):1709-1723. https://doi.org/10.1093/ajcn/nqz038.