Project Number: 8072-42000-082-12-N
Project Type: Non-Funded Cooperative Agreement
Start Date: May 1, 2018
End Date: Apr 30, 2020
1. Search for new natural plant antimicrobials by screening a natural plant extract library; 2. Study the mechanism of action of the antimicrobials using protein-ligand docking tools to synergize the application of plant compounds with known antimicrobials; 3. Study the coating plant compounds on material surfaces to control foodborne pathogens.
1. Plant extracts provided by the Baruch S. Blumberg Institute (Baruch) will be tested against foodborne pathogens to determine the minimal inhibition concentrations (MICs). 2. The plant extracts with activities will be tested at sub-lethal levels in biofilm assays to determine whether they inhibit biofilm formation. 3. Computational approaches will be implemented to design synergistic antimicrobial and plant compound combinations. 4. Plant compounds will be coated onto polymer surface for testing their antimicrobial properties.