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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Molecular Characterization of Foodborne Pathogens Research » Research » Research Project #434649

Research Project: Identification of New Plant Extracts that Possess Anti-bacterial Activities and Investigation of the Modes of Action Using System Biology

Location: Molecular Characterization of Foodborne Pathogens Research

Project Number: 8072-42000-082-12-N
Project Type: Non-Funded Cooperative Agreement

Start Date: May 1, 2018
End Date: Apr 30, 2020

Objective:
1. Search for new natural plant antimicrobials by screening a natural plant extract library; 2. Study the mechanism of action of the antimicrobials using protein-ligand docking tools to synergize the application of plant compounds with known antimicrobials; 3. Study the coating plant compounds on material surfaces to control foodborne pathogens.

Approach:
1. Plant extracts provided by the Baruch S. Blumberg Institute (Baruch) will be tested against foodborne pathogens to determine the minimal inhibition concentrations (MICs). 2. The plant extracts with activities will be tested at sub-lethal levels in biofilm assays to determine whether they inhibit biofilm formation. 3. Computational approaches will be implemented to design synergistic antimicrobial and plant compound combinations. 4. Plant compounds will be coated onto polymer surface for testing their antimicrobial properties.