Research Project: Identification of Disease Mechanisms and Control Strategies for Bacterial Respiratory Pathogens in Ruminants

Location: Ruminant Diseases and Immunology Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Identification of candidate genes and SNPs related to cattle temperament using a GWAS analysis coupled with an interacting network analysis - (Peer Reviewed Journal)
Paredes-Sanchez, F.A., Sifuentes-Rincon, A.M., Lara-Ramirez, E.E., Casas, E., Rodriguez-Almeida, F.A., Herrera-Mayorga, E.V., Randal, R.D. 2023. Identification of candidate genes and SNPs related to cattle temperament using a GWAS analysis coupled with an interacting network analysis. La Revista Mexicana de Ciencias Pecuarias. 14(1):1-22. https://doi.org/10.22319/rmcp.v14i1.6077.

MicroRNA profiles for different tissues from calves challenged with Mycoplasma bovis or challenged with Mycoplasma bovis and bovine viral diarrhea virus - (Peer Reviewed Journal)
Casas, E., Falkenberg, S.M., Dassanayake, R.P., Register, K.B., Neill, J.D. 2022. MicroRNA profiles for different tissues from calves challenged with Mycoplasma bovis or challenged with Mycoplasma bovis and bovine viral diarrhea virus. PLoS ONE. 17(7): Article e0271581. https://doi.org/10.1371/journal.pone.0271581.

Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-a, IL1-ß, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-y bovine IL-17A - (Peer Reviewed Journal)
Sacco, R.E., Elnaggar, M.M., Abdellrazeq, G.S., Fry, L.M., Hulubei, V., Davis, W.C., Harsla, T., Mucci, M.L. 2022. Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-a, IL1-ß, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-y bovine IL-17A. Veterinary Immunology and Immunopathology. 250. Article 110456. https://doi.org/10.1016/j.vetimm.2022.110456.

Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows - (Peer Reviewed Journal)
Eder, J.M., Sacco, R.E. 2022. Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows. Veterinary Immunology and Immunopathology. 248. Article 110418. https://doi.org/10.1016/j.vetimm.2022.110418.

Bovine NK-lysin peptides exert potent antimicrobial activity against multidrug-resistant Salmonella outbreak isolates - (Peer Reviewed Journal)
Dassanayake, R.P., Atkinson, B.M., Mulls, A.S., Falkenberg, S.M., Nicholson, E.M., Casas, E., Narasimhan, B., Bearson, S.M. 2021. Bovine NK-lysin peptides exert potent antimicrobial activity against multidrug-resistant Salmonella outbreak isolates. Nature Scientific Reports. 11(1). Article 19276. https://doi.org/10.1038/s41598-021-98860-6.

Application of four genotyping methods to Mycoplasma bovis isolates derived from western Canadian feedlot cattle - (Peer Reviewed Journal)
Kinnear, A., Waldner, M., Mccallister, T., Zaheer, R., Register, K.B., Jelinski, M. 2021. Application of four genotyping methods to Mycoplasma bovis isolates derived from western Canadian feedlot cattle. Journal of Clinical Microbiology. 59(7). Article e0004421. https://doi.org/10.1128/JCM.00044-21.

Bovine NK-lysin-derived peptides are bactericidal against Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Dassanayake, R.P., Wherry, T.L., Falkenberg, S.M., Reinhardt, T.A., Casas, E., Stabel, J.R. 2021. Bovine NK-lysin-derived peptides are bactericidal against Mycobacterium avium subspecies paratuberculosis. Veterinary Research. 52. Article 11. https://doi.org/10.1186/s13567-021-00893-2.

Serological evidence for historical and present-day exposure of North American bison to Mycoplasma bovis - (Peer Reviewed Journal)
Register, K.B., Parker, M., Patyk, K.A., Sweeney, S.J., Boatwright Jr, W.D., Jones, L.C., Woodbury, M., Hunter, D., Treanor, J., Kohr, M., Hamilton, R., Shury, T., Nol, P. 2021. Serological evidence for historical and present-day exposure of North American bison to Mycoplasma bovis. BMC Veterinary Research. 17. Article 18. https://doi.org/10.1186/s12917-020-02717-5.

Population genomic analysis of Mycoplasma bovis elucidates geographical variations and genes associated with host types - (Peer Reviewed Journal)
Kumar, R., Register, K.B., Christopher-Hennings, J., Moroni, P., Gioia, Gloria, Garcia-Fernandez, N., Nelson, J., Jelinski, M., Lysnyansky, I., Bayles, D.O., Alt, D.P., Scaria, J. 2020. Population genomic analysis of Mycoplasma bovis elucidates geographical variations and genes associated with host types. Microorganisms. 8(10). Article 1561. https://doi.org/10.3390/microorganisms8101561.

Novel genes involved in the genetic architecture of temperament in Brahman cattle - (Peer Reviewed Journal)
Paredes-Sanchez, F.A., Sifuentes-Rincon, A.M., Casas, E., Arellano-Vera, W., Parra-Bracamonte, G., Riley, D.G., Welsh Jr., T.H., Randel, R.D. 2020. Novel genes involved in the genetic architecture of temperament in Brahman cattle. PLoS ONE. 15(8). Article e0237825. https://doi.org/10.1371/journal.pone.0237825.

Mycoplasma bovis infections in free-ranging pronghorn, Wyoming, USA - (Peer Reviewed Journal)
Malmberg, J., O'Toole, D., Creekmore, T., Peckham, E., Killion, H., Vance, M., Ashley, R., Johnson, M., Anderson, C., Vasquez, M., Sandidge, D., Mildenberger, J., Hull, N., Bradway, D., Cornish, T., Register, K.B., Sondgeroth, K.S. 2020. Mycoplasma bovis infections in free-ranging pronghorn, Wyoming, USA. Emerging Infectious Diseases. 26(12):2807-2814. https://doi.org/10.3201/eid2612.191375.

Mycoplasma bovis results in fatal pneumonia in free-ranging pronghorn (antilocapra americana) - (Abstract Only)

Identification of a reliable fixative solution to preserve complex architecture of bacterial biofilms for scanning electron microscopy evaluation - (Peer Reviewed Journal)
Dassanayake, R.P., Falkenberg, S.M., Stasko, J.A., Shircliff, A.L., Lippolis, J.D., Briggs, R.E. 2020. Identification of a reliable fixative solution to preserve complex architecture of bacterial biofilms for scanning electron microscopy evaluation. PLoS One. 15(5):e0233973. https://doi.org/10.1371/journal.pone.0233973.

Complete genome sequences of 16 Mycoplasma bovis isolates from Canadian bison and cattle - (Peer Reviewed Journal)
Register, K.B., Bayles, D.O., Ma, H., Windeyer, C., Perez-Casal, J., Bras, A., Suleman, M., Woodbury, M., Jelinski, M., Alt, D.P. 2020. Complete genome sequences of 16 Mycoplasma bovis isolates from Canadian bison and cattle. Microbiology Resource Announcements. 9(23):e00325-20. https://doi.org/10.1128/MRA.00325-20.

Septicemic pasteurellosis causing necrotizing myositis in a beef cow (Bos taurus) in Alberta, Canada - (Peer Reviewed Journal)

Comparison of two multilocus sequence typing schemes for Mycoplasma bovis and revision of the pubMLST reference method - (Peer Reviewed Journal)
Register, K.B., Lysnyansky, I., Jelinski, M., Boatwright Jr, W.D., Waldner, M., Bayles, D.O., Pilo, P., Alt, D.P. 2020. Comparison of two multilocus sequence typing schemes for Mycoplasma bovis and revision of the pubMLST reference method. Journal of Clinical Microbiology. 58(6):e00283-20. https://doi.org/10.1128/JCM.00283-20.

Comparison of two schemes for multilocus sequence typing (MLST) of Mycoplasma bovis and revision of the pubMLST reference method - (Abstract Only)

Prevalence of Mycoplasma spp. in the respiratory tract of healthy North American bison (Bison bison) and comparison with serum antibody status - (Peer Reviewed Journal)
Register, K.B., Jones, L.C., Boatwright Jr, W.D., Shury, T.K., Woodbury, M., Hamilton, R.G., Treanor, J., Dyer, N., Nol, P. 2021. Prevalence of Mycoplasma spp. in the respiratory tract of healthy North American bison (Bison bison) and comparison with serum antibody status. Journal of Wildlife Diseases. 57(3):683-688. https://doi.org/10.7589/JWD-D-20-00198.

Overview of bordetellosis in poultry (Turkey coryza, Bordetella avium rhinotracheitis) - (Book / Chapter)
Register, K.B. 2020. Overview of bordetellosis in poultry (Turkey coryza, Bordetella avium rhinotracheitis). Merck Veterinary Manual. 1:1-6.

Comparison of multilocus sequence types found among recent North American isolates of Mycoplasma bovis from cattle, bison and deer - (Peer Reviewed Journal)
Register, K.B., Jelinski, M., Waldner, M., Boatwright Jr, W.D., Anderson, T.K., Hunter, D., Hamilton, R., Burrage, P., Shury, T., Bildfell, R., Wolff, P., Miskimins, D., Derscheid, R., Woodbury, M. 2019. Comparison of multilocus sequence types found among North American isolates of Mycoplasma bovis from cattle, bison and deer, 2007-2017. Journal of Veterinary Diagnostic Investigation. 31(6):899-904. https://doi.org/10.1177/1040638719874848.

Synthetic bovine NK-lysin-derived peptide (bNK2A) does not require intra-chain disulfide bonds for bactericidal activity - (Peer Reviewed Journal)
Dassanayake, R.P., Falkenberg, S.M., Nicholson, E.M., Briggs, R.E., Tatum, F.M., Sharma, V.K., Reinhardt, T.A. 2019. Synthetic bovine NK-lysin-derived peptide (bNK2A) does not require intra-chain disulfide bonds for bactericidal activity. PLoS One. 14(6). https://doi.org/10.1371/journal.pone.0218507.

Bovine NK-lysin-derived peptide NK2A demonstrates immunomodulatory activity on cattle leukocytes - (Abstract Only)

Comparison of Multilocus Sequence Types Found Among Recent North American Isolates of Mycoplasma bovis from Cattle, Bison and Deer - (Abstract Only)

Relative virulence in bison and cattle of bison-associated genotypes of mycoplasma bovis - (Peer Reviewed Journal)
Register, K.B., Olsen, S.C., Sacco, R.E., Ridpath, J., Falkenberg, S., Briggs, R., Kanipe, C., Madison, R. 2018. Relative virulence in bison and cattle of bison-associated genotypes of Mycoplasma bovis. Veterinary Microbiology. 222:55-63. https://doi.org/10.1016/j.vetmic.2018.06.020.

Bordetellosis (Turkey Coryza) - (Book / Chapter)

Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis - (Peer Reviewed Journal)
Dassanayake, R.P., Falkenberg, S.M., Register, K.B., Samorodnitsky, D., Nicholson, E.M., Reinhardt, T.A. 2018. Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis. PLoS One. 13(5):e0197677. https://doi.org/10.1371/journal.pone.0197677.

Characterization of alpha beta and gamma delta T cell subsets expressing IL-17A in ruminants and swine - (Peer Reviewed Journal)
Elnaggar, M.M., Abdellrazeq, G.S., Dassanayake, R.P., Fry, L.M., Hulubei, V., Davis, W.C. 2018. Characterization of alpha beta and gamma delta T cell subsets expressing IL-17A in ruminants and swine. Developmental and Comparative Immunology. 85:115-124. https://doi.org/10.1016/j.dci.2018.04.003.

Mistaken identity of a PCR target proposed for identification of Mycoplasma bovis and the effect of sequence variation on assay performance - (Abstract Only)

Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf - (Peer Reviewed Journal)
McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Scientific Reports. 8:3021. https://doi.org/10.1038/s41598-018-21292-2.

Mistaken identity of an open reading frame proposed for PCR-based identification of Mycoplasma bovis and the effect of polymorphisms and insertions on assay performance - (Peer Reviewed Journal)
Register, K.B., Boatwright Jr, W.D., Gesy, K.M., Thacker, T.C., Jelinski, M.D. 2018. Mistaken identity of an open reading frame proposed for PCR-based identification of Mycoplasma bovis and the effect of polymorphisms and insertions on assay performance. Journal of Veterinary Diagnostic Investigation. 30(4):637-641. https://doi.org/10.1177/1040638718764799.

Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis - (Abstract Only)

Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni - (Peer Reviewed Journal)
Dassanayake, R.P., Falkenberg, S.M., Briggs, R.E., Tatum, F.M., Sacco, R.E. 2017. Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. PLoS One. 12(8):1-14. doi. 10.1371/journal.pone.0183610.

Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni - (Abstract Only)

Pasteurellosis - (Book / Chapter)

A multiplex PCR assay for molecular capsular serotyping of Mannheimia haemolytica serotypes 1, 2, and 6 - (Peer Reviewed Journal)
Klima, C.L., Zaheer, R., Briggs, R.E., McAllister, T.A. 2017. A multiplex PCR assay for molecular capsular serotyping of Mannheimia haemolytica serotypes 1, 2, and 6. Journal of Microbiological Methods. 139(2017):155-160. doi. 10.1016/j.mimet.2017.05.010.

A serological investigation of the thirty-year history of exposure to Mycoplasma bovis in healthy North American bison - (Abstract Only)