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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Food Components and Health Laboratory » Research » Research Project #436407

Research Project: Absorption, Distribution, Metabolism and Excretion of Food Components and their Impact on Chronic Disease Risk

Location: Food Components and Health Laboratory

Project Number: 8040-51000-059-00-D
Project Type: In-House Appropriated

Start Date: Apr 30, 2019
End Date: Apr 29, 2024

Objective:
Objective 1: Determine the genotype, phenotype and food matrix factors that influence absorption, distribution, metabolism or excretion of glucosinolates, phenolics, and other food components. Objective 2: Determine how consumption of foods and food components, including but not limited to glucosinolates, phenolics, and carotenoids, modulate inflammatory and metabolic pathways that affect risk for cardiovascular diseases, diabetes, cancer, and other chronic disease.

Approach:
U.S. agriculture provides us with myriad dietary components that can have a significant impact on health. The human diet contains thousands of bioactive food components which have a multitude of physiologic actions, some of which can interrupt processes in the development of a host of chronic diseases. The goal of this project plan is to enhance the understanding of physiologic actions of diet-based bioactive compounds to improve their absorption and efficacy in promoting health and preventing disease. We have organized this project to address current and emerging nutrition issues while capitalizing on the experience and expertise of the research team assigned to this project. We will address the following factors for several different categories of food components and bioactives: how much of a dietary component we absorb from the food, how well we retain and utilize that dietary component, and how the bioactive compounds function in the body (mechanisms of action) to prevent the most significant modifiable health risks faced by American adults, including cardiovascular disease, diabetes, and cancer. Bioactive compounds will include polyphenols, carotenoids, and sulfur compounds from Brassica vegetables, because all demonstrate promising health benefits, and work with these compounds capitalizes on previous progress in our laboratory.