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ARS Home » Northeast Area » Boston, Massachusetts » People & Locations » Derek Fisher

Derek R Fisher
Boston, Massachusetts
Biologist

Phone: (617) 556-3225
Fax: (617) 556-3222

USDA-ARS-HNRCA
711 WASHINGTON STREET
BOSTON , MA 021110000

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Blueberries improve neuroinflammation and cognition differentially depending on individual cognitive baseline status -
Shukitt Hale, B., Nopporn, T., Miller, M.G., Poulose, S.M., Fisher, D.R. 2019. Blueberries improve neuroinflammation and cognition differentially depending on individual cognitive baseline status. Journal of Gerontology Biological Science. https://doi.org/10.1093/gerona/glz048.
The effects of intermittent wild blueberry feeding on inflammation and motor and cognitive behavior -
Fisher, D.R., Cahoon, D., Miller, M.G., Bielinski, D.F., Shukitt Hale, B. 2018. The effects of intermittent wild blueberry feeding on inflammation and motor and cognitive behavior [abstract]. 2018 Society for Neuroscience Annual Meeting Program # 291.17.
In vitro effects of a polyphenol-rich blueberry extract on adult human neural progenitor cells -
Zheng, T., Bielinski, D.F., Fisher, D.R., Shukitt Hale, B., Steindler, D.A. 2018. In vitro effects of a polyphenol-rich blueberry extract on adult human neural progenitor cells [abstract]. 2018 Society for Neuroscience Annual Meeting Program # 291.16.
Berry polyphenols are associated with enhanced cognition and reduced inflammation in healthy, older adults -
Shukitt Hale, B., Miller, M.G., Fisher, D.R., Bielinski, D.F., Scott, T.M. 2018. Berry polyphenols are associated with enhanced cognition and reduced inflammation in healthy, older adults [abstract]. 256th American Chemical Society National Meeting & Exposition Program #AGFD 21.
Berry fruit differentially improves age-related decrements in behavior based on baseline status -
Shukitt Hale, B., Miller, M.G., Bielinski, D.F., Fisher, D.R. 2018. Berry fruit differentially improves age-related decrements in behavior based on baseline status [abstract]. American Chemical Society Abstracts. 256th American Chemical Society National Meeting & Exposition Program. #AGFD 24.
Dietary intervention with blueberries and Epidiferphane (EDP) enhances calcium buffering in rat hippocampal neurons and reduces stress signaling in microglial cells -
Shukitt Hale, B., Fisher, D.R., Bielinski, D.F., Steindler, D., Zheng, T. 2018. Dietary intervention with blueberries and Epidiferphane (EDP) enhances calcium buffering in rat hippocampal neurons and reduces stress signaling in microglial cells [abstract]. Current Developments in Nutrition. 2(11):nzy043.
Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration -
Thangthaeng, N., Poulose, S., Fisher, D.R., Shukitt Hale, B. 2017. Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration. Nutrition Research. 49:88-95. https://doi.org/10.1016/j.nutres.2017.10.016.
Blueberry supplementation attenuates microglia activation and increases neuroplasticity in mice consuming a high fat diet Reprint Icon -
Carey, A.N., Gildawie, K.R., Rovnak, A., Thangthaeng, N., Fisher, D.R., Shukitt Hale, B. 2017. Blueberry supplementation attenuates microglia activation and increases neuroplasticity in mice consuming a high fat diet. Nutritional Neuroscience. https://doi.org/10.1080/1028415X.2017.1411875.
The relationship between berry polyphenols, inflammation, and cognitive function in older adults -
Shukitt Hale, B., Miller, M.G., Sandhu, A.K., Fisher, D.R., Scott, T.M., Burton-Freeman, B. 2017. The relationship between berry polyphenols, inflammation, and cognitive function in older adults [abstract]. E:\Papers\174-TopR-118.pdf.
Effect of blueberry and insulin on glucose-induced neurotoxicity in rat microglial cells -
Hininger, I., Thangthaeng, N., Bielinski, D., Fisher, D.R., Shukitt Hale, B., Poulose, S. 2017. Effect of blueberry and insulin on glucose-induced neurotoxicity in rat microglial cells. 8th International Conference on Polyphenols and Health (ICPH 2017) Abstract# 03-053.
Blueberry and EpidiferphaneTM (EDP) enhance calcium buffering in rat hippocampal cells and reduce stress signalling in microglial cells -
Fisher, D.R., Zheng, T., Bielinski, D.F., Steindler, D., Shukitt Hale, B. 2017. Blueberry and EpidiferphaneTM (EDP) enhance calcium buffering in rat hippocampal cells and reduce stress signalling in microglial cells. Society for Neuroscience Abstracts and Proceedings. Program #667.15.
In vitro effects of Epidiferphane™ on adult human neural progenitor cells -
Zheng, T., Bielinski, D., Fisher, D.R., Shukitt Hale, B., Reynolds, B., Steindler, D. 2017. In vitro effects of Epidiferphane™ on adult human neural progenitor cells. Society for Neuroscience Abstracts and Proceedings. Program #667.14.
The relationship between anthocyanins found in berry fruit, inflammation, and cognitive function in older adults -
Shukitt Hale, B., Miller, M.G., Thangthaeng, N., Fisher, D.R., Sandhu, A., Burton-Freeman, B. 2017. The relationship between anthocyanins found in berry fruit, inflammation, and cognitive function in older adults [abstract]. 9th International Workshop on Anthocyanins. p. 16.
Effects of blueberries on inflammation, motor performance and cognitive function -
Shukitt Hale, B., Miller, M.G., Thangthaeng, N., Fisher, D.R., Bielinski, D.F., Kelly, M.E., Scott, T. 2017. Effects of blueberries on inflammation, motor performance and cognitive function [abstract]. 21st International Association of Gerontology & Geriatrics (IAGG) World Congress, July 23-27, 2017, San Francisco, CA. doi:https://doi.org/10.1093/geroni/igx004.5010.
Tart cherry extracts reduce inflammatory and oxidative stress signaling in microglial cells -
Shukitt Hale, B., Kelly, M.E., Bielinski, D.F., Fisher, D.R. 2016. Tart cherry extracts reduce inflammatory and oxidative stress signaling in microglial cells. Antioxidants. doi: 10.3390/antiox5040033.
The beneficial effects of berry fruit on cognitive and neuronal function in aging -
Shukitt Hale, B., Miller, M.G., Thangthaeng, N., Fisher, D.R., Bielinski, D.F., Kelly, M.E., Scott, T. 2016. The beneficial effects of berry fruit on cognitive and neuronal function in aging. In: Proceedings of the 20th International Conference. Functional and Medical Foods for Chronic Diseases:Bioactive Compounds and Biomarkers, September 22-23, 2016, Boston, Massachusetts. p. 289-290.
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro -
Fisher, D.R., Miller, M.G., Thangthaeng, N., Kelly, M.E., Bielinski, D.F., Shukitt Hale, B. 2016. The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. Society for Neurscience 2016 Abstracts. Program No. 596.19.
The effects of blueberries on cognition and neuroplasticity -
Carey, A.N., Rovnak, A.M., Gildawie, K.R., Fisher, D.R., Shukitt Hale, B. 2016. The effects of blueberries on cognition and neuroplasticity. [abstract]. 252nd American Chemical Society National Meeting, Program #AGFD 161.
Berry fruit can improve age-associated neuronal and cognitive deficits: from the laboratory to the clinic -
Shukitt Hale, B., Miller, M.G., Thangthaeng, N., Fisher, D.R., Bielinski, D., Kelly, M.E., Tammy, S. 2016. Berry fruit can improve age-associated neuronal and cognitive deficits: from the laboratory to the clinic. American Aging Association. 72:61.
Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells -
Carey, A., Miller, M.G., Fisher, D.R., Bielinski, D., Gilman, C.K., Poulose, S.M., Shukitt Hale, B. 2017. Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells. Nutritional Neuroscience. 20:238-245.
Blueberries affect neuroinflammation and cognition differentially depending on individual cognitive baseline status -
Thangthaeng, N., Miller, M.G., Poulose, S.M., Bielinski, D.F., Fisher, D.R., Shukitt Hale, B. 2015. Blueberries affect neuroinflammation and cognition differentially depending on individual cognitive baseline status. Society for Neuroscience Abstracts and Proceedings. Society for Neuroscience Abstracts 2015, Program #767.03.
Walnuts improve neuronal and behavioral function in aging -
Shukitt Hale, B., Thangthaeng, N., Fisher, D.R., Bielinski, D.F., Poulose, S.M. 2015. Walnuts improve neuronal and behavioral function in aging. Federation of European Nutrition Societies European Nutrition Conference. Annals of Nutrition and Metabolism. Vol. 67 (Suppl. 1) p. 463.
Effects of dietary blueberry on cognition and in vivo and in vitro inflammatory status -
Miller, M.G., Fisher, D.R., Kelly, M.E., Bielinski, D.F., Shukitt Hale, B. 2015. Effects of dietary blueberry on cognition and in vivo and in vitro inflammatory status. Federation of American Societies for Experimental Biology Conference. 29:900.2.
Differential effects of blueberry polyphenols on age-associated neuroinflammation and cognition -
Thangthaeng, N., Miller, M.G., Poulose, S.M., Bielinski, D.F., Fisher, D.R., Shukitt Hale, B. 2015. Differential effects of blueberry polyphenols on age-associated neuroinflammation and cognition. Federation of American Societies for Experimental Biology Conference. 29:756-758.
Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in BV-2 microglial cells -
Fisher, D.R., Poulose, S.M., Bielinski, D.F., Shukitt Hale, B. 2014. Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in BV-2 microglial cells. Nutritional Neuroscience. 20(2):103-109. doi: 10.1179/1476830514Y.0000000150.
Tart cherry extracts reduce inflammatory stress signaling and enhance calcium buffering in microglial and neuronal cell lines -
Fisher, D.R., Bielinski, D., Kelly, M.E., Shukitt Hale, B. 2014. Tart cherry extracts reduce inflammatory stress signaling and enhance calcium buffering in microglial and neuronal cell lines. Society for Neuroscience Abstracts and Proceedings 2014. Program #144.18.
Serum metabolites from blueberry-supplemented older adults attenuate stress-induced neurotoxicity in HAPI microglial cells dependent on baseline cognitive status -
Shukitt Hale, B., Miller, M.G., Fisher, D.R. 2014. Serum metabolites from blueberry-supplemented older adults attenuate stress-induced neurotoxicity in HAPI microglial cells dependent on baseline cognitive status. Society for Neuroscience Abstracts and Proceedings. 2014. Program #144.16.
Walnut extracts protect cultured microglia against LPS-induced neurotoxicity via modulation of intracellular calcium concentration -
Thangthaeng, N., Poulose, S., Fisher, D.R., Shukitt Hale, B. 2014. Walnut extracts protect cultured microglia against LPS-induced neurotoxicity via modulation of intracellular calcium concentration. Society for Neuroscience Abstracts and Proceedings. 2014. Program #144.17.
Differential protective effects of serum metabolites from young and old walnut-fed rats against stress-induced neurotoxicity in BV-2 microglial cells -
Shukitt Hale, B., Fisher, D.R., Bielinski, D.F., Poulose, S.M. 2014. Differential protective effects of serum metabolites from young and old walnut-fed rats against stress-induced neurotoxicity in BV-2 microglial cells. [abstract]. American Aging Association. 127:73.
Restoration of stressor-induced calcium dysregulation and autophagy inhibition by polyphenol-rich acai (Euterpe sps.) fruit pulp extracts in rodent brain cells in vitro -
Poulose, S.M., Fisher, D.R., Bielinski, D., Gomes, S., Rimando, A., Schauss, A., Shukitt Hale, B. 2014. Restoration of stressor-induced calcium dysregulation and autophagy inhibition by polyphenol-rich acai (Euterpe sps.) fruit pulp extracts in rodent brain cells in vitro. Nutrition. 30: 853-862.
Dietery acai fruit improves cognition in aged rats -
Miller, M.G., Fisher, D.R., Carey, A.N., Poulose, S.M., Shukitt Hale, B. 2013. Dietery acai fruit improves cognition in aged rats. Society for Neuroscience Abstracts and Proceedings. 2013. Program # 252.04.
Dietery walnut alters neurochemical and behavioral functions in young and old rats -
Poulose, S.M., Fisher, D.R., Miller, M.M., Bielinski, D.F., Ramirez, F., Shukitt Hale, B. 2013. Dietery walnut alters neurochemical and behavioral functions in young and old rats. Society for Neuroscience Abstracts and Proceedings. 2013. Program #252.02.
Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia -
Carey, A.N., Fisher, D.R., Rimando, A.M., Gomes, S.M., Bielinski, D.F., Shukitt Hale, B. 2013. Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia. Journal of Agricultural and Food Chemistry. 61: 5979-5986.
Dietary acai fruit improves cognition and mobility in aged rats -
Miller, M.G., Fisher, D.R., Carey, A.N., Poulose, S.M., Shukitt Hale, B. 2013. Dietary acai fruit improves cognition and mobility in aged rats. Federation of American Societies for Experimental Biology Conference. Abstract 27:1083.3.
Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in brain cells in vitro -
Poulose, S.M., Fisher, D.R., Bielinski, D., Shukitt Hale, B. 2012. Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in brain cells in vitro [abstract]. Society for Neuroscience Abstracts and Proceedings. Paper No. 865:02.
The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells -
Carey, A.N., Fisher, D.R., Joseph, J.J., Shukitt Hale, B. 2013. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutritional Neuroscience. 16(1):13-20.
Anthocyanin-rich acai (Euterpe oleracea mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells -
Poulose, S.M., Fisher, D.R., Larson, J., Bielinski, D.F., Rimando, A.M., Carey, A.N., Schauss, A.G., Shukitt Hale, B. 2012. Anthocyanin-rich acai (Euterpe oleracea mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. Journal of Agricultural and Food Chemistry. 60:1084-1093.
Differential protection among fractionated blueberry polyphenolic families against DA-, ABeta 42 and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells -
Joseph, J.A., Shukitt Hale, B., Brewer, G.J., Weikel, K.A., Kalt, W., Fisher, D.R. 2010. Differential protection among fractionated blueberry polyphenolic families against DA-, ABeta 42 and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells. Journal of Agriculture and Food Chemistry. 58:8196-8204.
Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2 -
Willis, L., Bielinski, D.F., Fisher, D.R., Matthan, N.R., Joseph, J.A. 2010. Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2. Inflammation. 33(5):325.
Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cells involves alterations in stress signaling -
Joseph, J.A., Bielinski, D., Fisher, D.R. 2010. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cells involves alterations in stress signaling. Journal of Agricultural Food & Chemistry. 58:3380-3392.
Cellular and Behavioral Effects of Stilbene Resveratrol Analogs: Implications for Reducing the Deleterious Effects of Aging -
Joseph, J.A., Fisher, D.R., Cheng, V., Rimando, A.M., Shukitt Hale, B. 2008. Cellular and Behavioral Effects of Stilbene Resveratrol Analogs: Implications for Reducing the Deleterious Effects of Aging. Journal of Agriculture and Food Chemistry.56(22)10544-10551.
Blueberry Antagonism of C-2 Ceramide Disruption of CA2+ Responses and Recovery in MAChR-Transfected COS-7 Cells -
Joseph, J.A., Neuman, A., Bielinski, D.F., Fisher, D.R. 2008. Blueberry Antagonism of C-2 Ceramide Disruption of CA2+ Responses and Recovery in MAChR-Transfected COS-7 Cells. Journal of Alzheimer's Disease.15:429-441.
Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells -
Ghosh, D., Mcghie, T.K., Fisher, D.R., Joseph, J.A. 2007. Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells. Journal of the Science of Food and Agriculture. 87:2061-2067.
Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract -
Joseph, J.A., Carey, A.N., Brewer, G.J., Lau, F.C., Fisher, D.R. 2007. Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract. Journal of Alzheimer's Disease. 11:433-446.
Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract -
Joseph, J.A., Fisher, D.R., Carey, A.N., Bielinski, D.F. 2006. Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract. Journal of Alzheimer's Disease. 10:423-437.
BLUEBERRY EXTRACT ALTERS OXIDATIVE STRESS-MEDIATED SIGNALING IN COS-7 CELLS TRANSFECTED WITH SELECTIVELY VULNERABLE MUSCARINIC RECEPTOR SUBTYPES -
Joseph, J.A., Fisher, D.R., Bielinski, D. 2006. Blueberry extract alters oxidative stress-mediated signaling in cos-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. Journal of Alzheimer's Disease. 9(1):35-42.
BLUEBERRY EXTRACT INHIBITS DA-OR AB-INDUCED DECREMENTS IN CALCIUM FLUX IN PRIMARY HIPPOCAMPAL CELLS -
Joseph, J.A., Fisher, D.R. 2005. Blueberry extract inhibits da-or ab-induced decrements in calcium flux in primary hippocampal cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.6.
BLUEBERRY EXTRACT PREVENTS C-2 CERAMIDE DISRUPTION OF CA2+ BUFFERING IN MACHR-TRANSFECTED COS-7 CELLS -
Fisher, D.R., Bielinski, D.F., Joseph, J.A. 2005. Blueberry extract prevents c-2 ceramide disruption of ca2+ buffering in machr-transfected cos-7 cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.7
OXIDATIVE STRESS AND INFLAMMATION IN BRAIN AGING: NUTRITIONAL CONSIDERATIONS -
Joseph, J.A., Shukitt Hale, B., Casadesus, G., Fisher, D.R. 2005. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochemical Research. Volume(30):927-935
BLUEBERRY EXTRACT INHIBITS DA-INDUCED INCREASES IN MAPK SIGNALING IN MUSCARINIC M1 AND M3-TRANSFECTED COS-7 CELLS -
Joseph, J.A., Bielinski, D., Fisher, D.R. 2004. Blueberry extract inhibits DA-induced increases in MAPK signaling in Muscarinic M1 and M3-transfected COS-7 cells. Soc.Neurosci. Abs. 2004, 30, 1017.17.
THE M3 MUSCARINIC RECEPTOR I3 DOMAIN CONFERS OXIDATIVE STRESS PROTECTION ON CALCIUM REGULATION IN TRANSFECTED COS-7 CELLS -
Joseph, J.A., Fisher, D.R., Carey, A.N., Szprengiel, A. 2004. The m3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected cos-7 cells. Aging Cell (2004)3, pp263-271.
FRUIT EXTRACTS ANTAGONIZE AB-OR DA-INDUCED DEFICITS IN CA2+ FLUX IN M1-TRANSFECTED COS-7 CELLS -
Joseph, J.A., Fisher, D.R., Carey, A.N. 2004. Fruit extracts antagonize ab-or da-induced deficits in ca2+ flux in m1-transfected cos-7 cells. Journal of Alzheimer's Disease 6(2004) 403-411.
MUSCARININC RECEPTOR SUBTYPE DETERMINES VULNERABILITY TO AMYLOD BETA TOXICITY IN TRANSFECTED COS-7 CELLS -
Joseph, J.A., and Fisher, D.R. Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected COS 7 cells. J. Alz. Dis. 2003. 5: 197-208.
MUSCARINIC RECEPTOR SUBTYPE DETERMINES VULNERABILITY TO OXIDATIVE STRESS IN COS-7 CELLS -
Joseph, J.A., Fisher, D.R., and Strain, J. Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells. Free Rad. Biol. Med. 2002, 32: 153-161.