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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » People & Locations » Lowell Kappmeyer

Lowell S Kappmeyer
Animal Disease Research
Geneticist

Phone: (509) 335-6059
Fax: (509) 335-8328

3053 ADBF, WSU
PULLMAN, WA 991646630
Projects
Genetic Impact and Improved Diagnostics for Sheep and Goat Transmissible Spongiform Encephalopathies
In-House Appropriated (D)
  Accession Number: 431730
Identification of Host Factors and Immunopathogenesis of Pneumonia in Domestic and Bighorn Sheep
In-House Appropriated (D)
  Accession Number: 431731
Identification of Tick Colonization Mechanisms and Vaccine Development for Anaplasmosis
In-House Appropriated (D)
  Accession Number: 431740
Development of Detection and Control Strategies for Bovine Babesiosis and Equine Piroplasmosis
In-House Appropriated (D)
  Accession Number: 431742

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Identification and antigenicity of the spherical body protein-4 (SBP-4) of Babesia caballi Reprint Icon - (Peer Reviewed Journal)
Mahmoud, M.S., Kandil, O.M., Abu El-Ezz, N.T., Hendawy, S.H., Elsawy, B.S., Knowles, D.P., Bastos, R.G., Kappmeyer, L.S., Laughery, J.M., Alzan, H.F., Suarez, C.E. 2020. Identification and antigenicity of the spherical body protein-4 (SBP-4) of Babesia caballi. Parasites & Vectors. 13:369. https://doi.org/10.1186/s13071-020-04241-9.
Equid infective Apicomplexa cluster in multiple 18S rDNA gene clades comprising distinct taxa and have exceptionally diverse mammalian and tick host ranges Reprint Icon - (Peer Reviewed Journal)
Bishop, R.P., Kappmeyer, L.S., Onzere, C.K., Odongo, D.O., Githaka, N., Sears, K.P., Knowles, D. , Fry, L.M. 2020. Equid infective Apicomplexa cluster in multiple 18S rDNA gene clades comprising distinct taxa and have exceptionally diverse mammalian and tick host ranges. Parasites & Vectors. 13:261. https://doi.org/10.1186/s13071-020-04131-0.
Infection dynamics of Theileria equi and Theileria haneyi, a newly discovered apicomplexan of the horse Reprint Icon - (Peer Reviewed Journal)
Sears, K.P., Kappmeyer, L.S., Wise, L.N., Siva, M., Ueti, M.W., White, S.N., Reif, K.E., Knowles, D.P. 2019. Infection dynamics of Theileria equi and Theileria haneyi, a newly discovered apicomplexan of the horse. Veterinary Parasitology. 271:68-75. https://doi.org/10.1016/j.vetpar.2019.06.009.
Evolution and diversity of the EMA families of the divergent equid parasites, Theileria equi and T. haneyi Reprint Icon - (Peer Reviewed Journal)
Wise, L.N., Kappmeyer, L.S., Knowles, D.P., White, S.N. 2019. Evolution and diversity of the EMA families of the divergent equid parasites, Theileria equi and T. haneyi. Infection, Genetics and Evolution. 68:153-160. https://doi.org/10.1016/j.meegid.2018.12.020.
Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance Reprint Icon - (Peer Reviewed Journal)
Knowles, D.P., Kappmeyer, L.S., Haney, D., Herndon, D.R., Fry, L.M., Munro, J.B., Sears, K., Ueti, M.W., Wise, L.N., Silva, M., Schneider, D.A., Grause, J., White, S.N., Trentina, K., Bishop, R., Odongo, D.O., Pelzel-McCluske, A.M., Scoles, G.A., Mealey, R.H., Silva, J.C. 2018. Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance. International Journal for Parasitology. 48(9-10):127-137. https://doi.org/10.1016/j.ijpara.2018.03.010.
Verification of post-chemotherapeutic clearance of theileria equi through concordance of nested PCR and immunoblot - (Peer Reviewed Journal)
Wise, L.N., Kappmeyer, L.S., Dasilva, M., White, S.N., Grause, J.F., Knowles Jr, D.P. 2017. Verification of post-chemotherapeutic clearance of theileria equi through concordance of nested PCR and immunoblot. Ticks and Tick Borne Diseases. https://doi.org/10.1016/j.ttbdis.2017.08.007.
Analysis of stage-specific protein expression during babesia bovis development within female rhipicephalus microplus - (Peer Reviewed Journal)
Johnson, W.C., Taus, N.S., Reif, K.E., Bohaliga, G., Kappmeyer, L.S., Ueti, M.W. 2017. Analysis of stage-specific protein expression during babesia bovis development within female rhipicephalus microplus. Journal of Proteome Research. 16(3):1327-1338.
Expression of 6-Cys gene superfamily defines babesia bovis sexual stage development within rhipicephalus microplus - (Peer Reviewed Journal)
Alzan, H.F., Lau, A., Knowles, D.P., Herndon, D.R., Ueti, M.W., Scoles, G.A., Kappmeyer, L.S., Suarez, C.E. 2016. Expression of 6-Cys gene superfamily defines babesia bovis sexual stage development within rhipicephalus microplus. PLoS One. doi:10.1371/journal.pone.0163791.
Assessment of theileria equi and babesia caballi infections in equine populations in Egypt by molecular, serological and hematological approaches - (Peer Reviewed Journal)
Mahmoud, M.S., Abu El-Ezz, N.T., Abdel-Shafy, S., Nassar, S.A., El Namaky, A.H., Khalil, W.B., Knowles Jr, D.P., Kappmeyer, L.S., Silva, M.G., Suarez, C.E. 2016. Assessment of theileria equi and babesia caballi infections in equine populations in Egypt by molecular, serological and hematological approaches. Parasites & Vectors. doi: 10.1186/s13071-016-1539-9.
Superinfection exclusion of the ruminant pathogen anaplasma marginale in the tick vector is dependent on time between exposures to the strains - (Peer Reviewed Journal)
Noh, S.M., Dark, M.J., Reif, K.E., Ueti, M.W., Kappmeyer, L.S., Scoles, G.A., Palmer, G.H., Brayton, K.A. 2016. Superinfection exclusion of the ruminant pathogen anaplasma marginale in the tick vector is dependent on time between exposures to the strains. Applied and Environmental Microbiology. 82(11):3217-3124.
Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor - (Peer Reviewed Journal)
Hines, S.A., Ramsay, J.D., Kappmeyer, L.S., Lau, A.O., Ojo, K.K., Vanvoorhis, W., Knowles Jr, D.P., Mealey, R.H. 2015. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor. Parasites & Vectors. doi: 10.1186/s13071-014-0611-6.
Review of equine piroplasmosis ()
Wise, L.N., Kappmeyer, L.S., Mealy, R.H., Knowles Jr, D.P. 2013. Review of equine piroplasmosis. Journal of Veterinary Internal Medicine. 27(6):1334-46.
Improved diagnostic performance of a commercial anaplasma antibody competitive enzyme-linked immunosorbent assay using recombinant major surface protein 5–glutathione S-transferase fusion protein as antigen - (Peer Reviewed Journal)
Chung, C., Wilson, C., B. Mudiyanselage, C.B., Kang, E., Adams, S.D., Kappmeyer, L.S., Knowles Jr, D.P., Mcelwain, T., Evermann, J., Ueti, M.W., Scoles, G.A., Lee, S.S., Mcguire, T.C. 2014. Improved diagnostic performance of a commercial anaplasma antibody competitive enzyme-linked immunosorbent assay using recombinant major surface protein 5–glutathione S-transferase fusion protein as antigen. Journal of Veterinary Diagnostic Investigation. 26(1):61-71.
Serum antibodies from a subset of horses positive for babesia caballi by competitive enzyme-linked immunosorbent assay demonstrate a protein recognition pattern that is not consistent with infection - (Peer Reviewed Journal)
Awinda, P.O., Mealey, R.H., Williams, L.B., Conrad, P.A., Packham, A.E., Reif, K.E., Grause, J.F., Pelzel-Mccluskey, A.M., Chung, C., Reginaldo, B., Kappmeyer, L.S., Howe, D.K., Ness, S.L., Knowles Jr, D.P., Ueti, M.W. 2013. Serum antibodies from a subset of horses positive for babesia caballi by competitive enzyme-linked immunosorbent assay demonstrate a protein recognition pattern that is not consistent with infection. Clinical and Vaccine Immunology. 20(11):1752-1757.
Diagnosis of theileria equi infections in horses in the Azores using cELISA and nested PCR - (Peer Reviewed Journal)
Baptista, C., Lopes, M.S., Tavares, A.C., Rojer, H., Kappmeyer, L.S., Mendonça, D., Da Câmara Machado, A. 2013. Diagnosis of theileria equi infections in horses in the Azores using cELISA and nested PCR. Ticks and Tick Borne Diseases. 4(3):242-245.
Genetic characterization of theileria equi infecting horses in North America: evidence for a limited source of U.S. introductions - (Peer Reviewed Journal)
Hall, C.M., Busch, J.D., Palma-Cagle, K.A., Scoles, G.A., Ueti, M.W., Kappmeyer, L.S., Wagner, D.M. 2013. Genetic characterization of theileria equi infecting horses in North America: evidence for a limited source of U.S. introductions. International Journal for Parasitology. doi:10.1186/PV.1756-3305-6-35.
Comparative genomic analysis and phylogenetic position of Theileria equi Reprint Icon - (Peer Reviewed Journal)
Kappmeyer, L.S., Thiagarajan, M., Herndon, D.R., Ramsay, J.D., Caler, E., Djikeng, A., Gillespie, J.J., Lau, A.O., Roalson, E.H., Silva, J.C. 2012. Comparative genomic analysis and phylogenetic position of Theileria equi. Biomed Central (BMC) Genomics. BMC Genomics 2012, 13:603.
Efficacy of imidocarb dipropionate in the elimination of Theileria equi in experimentally infected horses - (Peer Reviewed Journal)
Grause, J.F., Ueti, M.W., Nelsona, J.T., Knowles Jr, D.P., Kappmeyer, L.S., Bunn, T.O. 2012. Efficacy of imidocarb dipropionate in the elimination of Theileria equi in experimentally infected horses. The Veterinary Journal. 10.1016/j.tvjl.2012.10.025.
Re-emergence of the apicomplexan theileria equi in the United States: Elimination of persistent infection and transmission risk Reprint Icon - (Peer Reviewed Journal)
Ueti, M.W., Mealey, R.H., Kappmeyer, L.S., White, S.N., Kumpula-Mcwhirter, N., Pelzel, A.M., Grause, J.F., Bunn, T.O., Schwartz, A., Traub-Dargatz, J.L. 2012. Re-emergence of the apicomplexan theileria equi in the United States: Elimination of persistent infection and transmission risk. PloSONE 7(9):e44713.
In vitro activity of ponazuril against Theileria equi Reprint Icon - (Peer Reviewed Journal)
Wise, L.N., Ueti, M.W., Kappmeyer, L.S., Hines, M.T., White, S.N., Davis, W., Knowles Jr, D.P. 2012. In vitro activity of ponazuril against Theileria equi. Veterinary Parasitology. 185(2-4):282-5.
Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency Reprint Icon - (Peer Reviewed Journal)
Mealey, R.H., Kappmeyer, L.S., Ueti, M.W., Wagner, B., Knowles Jr, D.P. 2011. Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency. Clinical and Vaccine Immunology. 19(1):100-4.
Bm86 midgut protein sequence variation in south Texas cattle fever ticks - (Peer Reviewed Journal)
Freeman, J.M., Davey, R.B., Kappmeyer, L.S., Kammlah, D.M., Olafson, P.U. 2010. Bm86 midgut protein sequence variation in south Texas cattle fever ticks. Parasites & Vectors. 3;3:101.
A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites - (Peer Reviewed Journal)
Freeman, J.M., Kappmeyer, L.S., Ueti, M.W., Mcelwain, T.F., Baszler, T.V., Echaide, I., Nene, V.M., Knowles Jr, D.P. 2010. A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites. Veterinary Parasitology. 173(3-4):211-218.
blaCMY-2-positive IncA/C plasmids from escherichia coli and salmonella enterica are a distinct component of a larger lineage of plasmids - (Peer Reviewed Journal)
Call, D.R., Singer, R.S., Meng, D., Broschat, S.L., Orfe, L.H., Anderson, J.M., Herndon, D.R., Kappmeyer, L.S., Daniels, J.B., Besser, T.E. 2010. blaCMY-2-positive IncA/C plasmids from escherichia coli and salmonella enterica are a distinct component of a larger lineage of plasmids. Antimicrobial Agents and Chemotherapy. 54(2):590-6.
Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential - (Peer Reviewed Journal)
Schwint, O.N., Ueti, M.W., Palmer, G.H., Kappmeyer, L.S., Hines, M.T., Cordes, R.T., Knowles Jr, D.P., Scoles, G.A. 2009. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrobial Agents and Chemotherapy. 53(10):4327-4332.
Conservation in the face of diversity: multistrain analysis of an intracellular bacterium - (Peer Reviewed Journal)
Dark, M.J., Herndon, D.R., Kappmeyer, L.S., Gonzales, M.P., Nordeen, E., Palmer, G.H., Knowles Jr, D.P., Brayton, K.A. 2009. Conservation in the face of diversity: multistrain analysis of an intracellular bacterium. Biomed Central (BMC) Genomics. 10:16.
Persistently Infected Horses Are Reservoirs for Intrastadial Tick-Borne Transmission of the Apicomplexan Parasite Babesia equi - (Peer Reviewed Journal)
Ueti, M.W., Palmer, G.H., Scoles, G.A., Kappmeyer, L.S., Knowles Jr, D.P. 2008. Persistently Infected Horses Are Reservoirs for Intrastadial Tick-Borne Transmission of the Apicomplexan Parasite Babesia equi. Infection and Immunity. 76(8):3525-3529.
Transmission of Babesia caballi by Dermacentor nitens (Acari: Ixodidae) Is Restricted to One Generation in the Absense of Alimentary Reinfection on a Susceptible Equine Host - (Peer Reviewed Journal)
Schwint, N.O., Knowles Jr, D.P., Ueti, M.W., Kappmeyer, L.S., Scoles, G.A. 2008. Transmission of Babesia caballi by Dermacentor nitens (Acari: Ixodidae) Is Restricted to One Generation in the Absense of Alimentary Reinfection on a Susceptible Equine Host. Journal of Medical Entomology. 45(6):1152-1155.
Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci - (Peer Reviewed Journal)
Hoesing, L.M., White, S.N., Kappmeyer, L.S., Herndon, D.R., Knowles Jr, D.P. 2008. Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci. Immunogenetics. 60(3):167-176.
Genome Sequence of Babesia bovis and Camparative Analysis of Apicomplexan Hemoprotozoa - (Peer Reviewed Journal)
Brayton, K., Lau, A.O., Herndon, D.R., Hannick, L., Kappmeyer, L.S., Berens, S.J., Bidwell, S.L., Brown, W.C., Crabtree, J., Fadrosh, D., Feldblum, T., Forberger, H.A., Haas, B.J., Howell, J.M., Khouri, H., Koo, H., Mann, D.J., Norimine, J., Paulsen, I.T., Radune, D., Ren, Q., Smith, R.K., Suarez, C.E., White, O., Wortman, J.R., Knowles Jr, D.P., Mcelwain, T.F., Nene, V.M. 2007. Genome Sequence of Babesia bovis and Camparative Analysis of Apicomplexan Hemoprotozoa. PLoS Pathogens. 3(10):1401-1413.
DEVELOPMENT OF SPECIFIC IMMUNOGLOBULIN GA (IGGA) AND IGGB ANTIBODIES CORRELATES WITH CONTROL OF PARASITEMIA IN BABESIA EQUI INFECTION - (Peer Reviewed Journal)
Cunha, C.W., Mcguire, T.C., Kappmeyer, L.S., Hines, S.A., Lopez, A., Dellagostin, O.A., Knowles Jr, D.P. 2006. Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia equi Infection. Clinical and Vaccine Immunology. 13(2):297-300.
ABILITY OF THE VECTOR TICK BOOPHILUS MICROPLUS TO ACQUIRE AND TRANSMIT BABESIA EQUI FOLLOWING FEEDING ON CHRONICALLY INFECTED HORSES WITH LOW LEVEL PARASITEMIA - (Peer Reviewed Journal)
Ueti, M.W., Palmer, G.H., Kappmeyer, L.S., Statdfield, M., Scoles, G.A., Knowles Jr, D.P. 2005. Ability of the Vector Tick Boophilus microplus To Acquire and Transmit Babesia equi following Feeding on Chronically Infected Horses with Low-Level Parasitemia. Journal of Clinical Microbiology. 43(8):3755-3759.
COMPLETE GENOME SEQUENCING OF ANAPLASMA MARGINALE REVEALS THAT THE SURFACE IS SKEWED TO TWO SUPERFAMILIES OF OUTER MEMBRANE PROTEINS - (Peer Reviewed Journal)
Brayton, K.A., Kappmeyer, L.S., Herndon, D.R., Dark, M.J., Tibbals, D.L., Palmer, G.H., Mcguire, T.C., Knowles Jr, D.P. 2005. Complete genome sequencing of anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proceedings of the National Academy of Sciences. 102(3):844-849.
EXPRESSION OF EQUI MEROZOITE ANTIGEN 2 DURING DEVELOPMENT OF BABESIA EQUI IN THE MIDGUT AND SALIVARY GLAND OF THE VECTOR TICK BOOPHILUS MICROPLUS - (Peer Reviewed Journal)
Ueti, M.W., G.H. Palmer, L.S. Kappmeyer, G.A. Scoles and D.P. Knowles. 2003. Expression of Equi Merozoite Antigen 2 during Development of Babesia equi in the Midgut and Salivary Gland of the vector tick Boophilus microplus. J. Clin. Micro. 41(12):5803-5809.
CONFORMATIONAL DEPENDENCE AND CONSERVATION OF AN IMMUNODOMINANT EPITOPE WITHIN THE BABESIA EQUI ERYTHROCYTE-STAGE SURFACE PROTEIN EQUI MEROSOITE ANTIGEN 1 - (Peer Reviewed Journal)
Clinical & Diagnostic Lab. Immunol.9(6)2002 1301-1306
DETECTION OF EQUINE ANTIBODIES TO BABESIA CABALLI BY RECOMBINANT B. CABALLIRHOPTRY-ASSOCIATED PROTEIN 1 IN COMPETITIVE-INHIBITION ENZYME-LINKED IMMUNOSORBENT ASSAY - (Peer Reviewed Journal)
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