|Lopez, A. Marianela|
|Knowles, Donald - Don|
Submitted to: Clinical and Vaccine Immunology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/12/2005
Publication Date: 2/5/2006
Citation: Cunha, C.W., Mcguire, T.C., Kappmeyer, L.S., Hines, S.A., Lopez, A., Dellagostin, O.A., Knowles Jr, D.P. 2006. Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia equi Infection. Clinical and Vaccine Immunology. 13(2):297-300. Interpretive Summary: Development of safe and efficacious vaccines for complex parasities such as Babesia equi requires and understanding of markers of protective immunity. This works shows that specific components (IgG isotypes) of the horses immune system correlate with parasite control during acute infection. Also, this component profile can be reproduced by immunization with the adjuvant saponin.
Technical Abstract: In this study, the kinetics of specific IgG isotypes were characterized in Babesia equi (Theileria equi) infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute parasitemia. The same IgG isotype profile induced during acute infection was also obtained by EMA-1/saponin immunization.