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United States Department of Agriculture

Agricultural Research Service

USDA Researchers Improve Newcastle Disease Classification System / March 24, 2014 / News from the USDA Agricultural Research Service
Read the magazine story to find out more.

Photo: ARS microbiologist Darrell Kapczynski gives a baby chick a vaccine against Newcastle disease. Link to photo information
ARS researchers have developed new information to help improve protection of poultry from Newcastle disease viruses, including when to vaccinate chicks. Click the image for more information about it.


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USDA Researchers Improve Newcastle Disease Classification System

By Sandra Avant
March 24, 2014

U.S. Department of Agriculture (USDA) scientists have given the Newcastle disease classification system a much-needed update, making it easier to identify virus types.

Exotic Newcastle disease, an extremely virulent form of the virus, is not found in poultry in the United States but is widespread in Asia, Africa, Mexico and many countries in South America. It affects chickens and other bird species, and is often fatal, killing about 80 to 100 percent of unvaccinated infected birds.

At the Agricultural Research Service (ARS) Southeast Poultry Research Laboratory (SEPRL) in Athens, Ga., microbiologist Claudio Afonso, veterinary medical officer Patti Miller and their colleagues examine genetic differences in Newcastle disease viruses from other countries, characterize them, make sure existing tests and vaccines are effective, and work on strategies to develop better vaccines. In addition, they evaluate systems used to classify virus isolates.

Afonso recently proposed a new classification system to group Newcastle isolates. Traditionally, two systems were being used simultaneously to classify isolates into lineages or genotypes. This caused confusion and sometimes incorrect classification of isolates.

The new single system, which is detailed in research published in Infection, Genetics and Evolution, is reliable and consistent and can be used by any laboratory worldwide.

SEPRL scientists also evaluate the ability of current vaccines to protect against emerging Newcastle viruses and help the poultry industry test improved vaccines.

In other research, Miller is studying the role a bird's immunity plays in virus transmission, protection against disease and relationships between genotypes. Her recent finding, published in Developmental & Comparative Immunology, suggest that an earlier onset of immunity may be necessary for future vaccines to protect against transmission and spread of Newcastle disease.

ARS is USDA's principal intramural scientific research agency.

Read more about this research in the March 2014 issue of Agricultural Research magazine.

Last Modified: 9/17/2014
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