Skip to main content
ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #307160

Title: Antileukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora

Author
item METWALY, AHMED - University Of Mississippi
item FRONCZEK, FRANK - University Of Mississippi
item MA, GUOYI - University Of Mississippi
item KADRY, HAZEM - University Of Mississippi
item EL-HELA, ATEF - University Of Mississippi
item MOHAMMAD, ABD-ELSALAM - University Of Mississippi
item CUTLER, STEPHEN - University Of Mississippi
item ROSS, SAMIR - University Of Mississippi

Submitted to: Tetrahedron Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/23/2014
Publication Date: 5/2/2014
Citation: Metwaly, A.M., Fronczek, F.R., Ma, G., Kadry, H.A., El-Hela, A.A., Mohammad, A.I., Cutler, S.J., Ross, S. 2014. Antileukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora. Tetrahedron Letters. 55:3478-3481.

Interpretive Summary: Four new and two known alpha-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified by spectroscopic analyses. Two compounds showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 lM and against K562 cells with IC50 values of 4.5 and 1.5 lM, respectively.

Technical Abstract: Four new (1–4) and two known (5 and 6)a-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identi'ed to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (2) 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3)4-methoxy-6- methyl-5-(3-oxobutyl)-2H-pyran-2-one (4),5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5)and 5-[(2E)-but-2-en-1-yl]-4-methoxy-6-methyl-2H-pyran-2-one(6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 lM and against K562 cells with IC50 values of 4.5 and 1.5 lM, respectively.