Location: Natural Products Utilization ResearchTitle: Utilization of phylogenetic information to aid in the discovery of novel bioactive constituents from soil Streptomyces sp
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 2/20/2023
Publication Date: 4/25/2023
Citation: Kim, S., Tamang, P., Estep Iii, A.S., Cantrell, C.L. 2023. Utilization of phylogenetic information to aid in the discovery of novel bioactive constituents from soil Streptomyces sp. Meeting Abstract. International Conference on the Science of Botanicals, Oxford, MS.
Technical Abstract: The rise in resistance among pathogenic microorganisms to many commonly used synthetic pesticides led us to a search for new natural product-based solutions. Streptomyces bacteria, commonly found in soil and known to play a crucial role in organic material decomposition, are being studied as a potential source of eco-friendly biopesticides, both antifungals and mosquito larvicides. Our focus is on unstudied Streptomyces species and their secondary metabolites. We have recently reported Streptomyces distallicus and its potential as a biopesticide against Aedes aegypti. Furthermore, our findings indicate that S. distallicus and its extracts are a promising source of microbial biolarvicides. The objective of this study was to study six Streptomyces sp. from soils (i.e., Streptomyces ardus, Streptomyces kentuckensis, Streptomyces eurocidicus, Streptomyces salmonis, Streptomyces hachijoensis, and Streptomyces septatus) related with DNA to Streptomyces distallicus for potential use as microbial biopesticides, plant protectants, or as a source of biochemical biopesticides with agriculturural applications. The culture filtrate of Streptomyces sp. were extracted using ethyl acetate and analyzed with advanced technology. Potent bioactive substances were tested using various in-house tests to determine their efficacy against phytopathogenic fungi and against Aedes aegypti larvae. Research is ongoing to identify specific bioactive compounds, understand their chemical pathways, and conduct further physiological studies.