Location: Endemic Poultry Viral Diseases ResearchTitle: The Emergence, Diversification, and Transmission of Subgroup J Avian Leukosis Virus Reveals that the Live Chicken Trade Plays a Critical Role in the Adaption and Endemicity of Viruses to the Yellow-Chickens
|DENG, QIAOMU - Guangxi University|
|LI, QIUHONG - Guangxi University|
|LI, MIN - Guangxi University|
|ZHANG, SHENGBIN - Yongxin Husbandry Group Of Xijiang Co, Ltd|
|WANG, PEIKUN - Linyi University|
|FU, FUMEI - Guangxi University|
|ZHU, WEIVU - Guangxi University|
|WEI, TIANCHAO - Guangxi University|
|MO, MEILAN - Guangxi University|
|HUANG, TENG - Guangxi University|
|WEI, PING - Guangxi University|
Submitted to: Journal of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/4/2022
Publication Date: 8/12/2022
Citation: Deng, Q., Li, Q., Li, M., Zhang, S., Wang, P., Fu, F., Zhu, W., Wei, T., Mo, M., Huang, T., Zhang, H., Wei, P. 2022. The Emergence, Diversification, and Transmission of Subgroup J Avian Leukosis Virus Reveals that the Live Chicken Trade Plays a Critical Role in the Adaption and Endemicity of Viruses to the Yellow-Chickens. Journal of Virology. https://doi.org/10.1128/jvi.00717-22.
Interpretive Summary: Although avian leukosis (AL) is not a current threat to the US poultry industry, it continues to pose a critical threat outside the US and creates hurdles that prevent international free trade of poultry. This study systematically analyzed a gene sequence of the avian leukosis viruses that were isolated from diseased chicken samples where AL outbreaks took place in multiple countries over the last three decades. The findings provided vital epidemiology information, which would lead to strategical improvement on the disease control, therefore, benefiting the world poultry industry and the consumers.
Technical Abstract: The geographical spread and inter-host transmission of the subgroup J avian leukosis virus (ALV-J) may be the most important issues for the epidemiological study. An integrated analysis, including phylogenetic trees, amino acid (aa)-mutation screening, selection analysis, evolutionary dynamics, and viral transmission, based on the sequences of gp85 gene of 665 ALV-J isolates collected during 1988-2020, was performed. Our results suggested a new Clade 3 emerging in East and South China while the Clades 1.1 and 1.3 viruses were prevailing in the Guangxi area. Phylodynamic analysis indicated that the early USA strains appeared much earlier than that of the prototype strain HPRS-103 in the UK., and layers in East China and the Yellow chickens in South China acted as the major sources of diffusion and infection centers for Clade 1.2 and 1.3 viruses, respectively. The Yellow chickens have been primarily facing the risk of Clade 2 virus infection. Our findings provide new insights for ALV-J epidemiology, which may advance the understanding on critical factors involved in ALV-J dissemination and emergence.