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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #390012

Research Project: Intervention Strategies to Prevent and Control Immunosuppressive Viruses of Poultry Associated with Secondary Pathogen Infections

Location: Endemic Poultry Viral Diseases Research

Title: Evaluation of host genetic resistance to infectious bursal disease virus

item Blakey, Julia
item GARCIA, MARICARMEN - University Of Georgia
item MAEKAWA, DANIEL - University Of Georgia
item Spackman, Erica
item Dunn, John

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 12/17/2021
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Ten lines of MHC-B congenic SPF chickens and two lines of SPF chickens with similar B haplotype but differing non-MHC genes were utilized to investigate the effect of MHC-B haplotype on infectious bursal disease (IBD) incidence. Chickens were challenged at 28 days of age with AL-2, STC, or rA strains of infectious bursal disease virus (IBDV). IBD severity was evaluated throughout a seven-day course of infection based on mortality rates and bursal lesion scoring from H&E bursal sections. Results demonstrated that both the MHC-B haplotype and IBDV virus strain impacted IBD susceptibility. MHC-B congenic lines B*13 and B*19 were consistently in the most IBD susceptible group, while several other B congenic lines were determined as intermediate susceptibility based on survival and bursal scores. IBDV strain rA separated the chicken lines best by mortality, while IBDV strain STC best highlighted differences based on bursal lesions.