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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #353847

Research Project: Genetic and Biological Determinants of Avian Herpesviruses Pathogenicity, Transmission, and Evolution to Inform the Development of Effective Control Strategies

Location: Endemic Poultry Viral Diseases Research

Title: Genomic sequence analysis of Gallid herpesvirus 3 vaccine strain 301B/1

item Kim, Taejoong
item Spatz, Stephen
item VOLKENING, JEREMY - Base2bio

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/14/2018
Publication Date: 7/14/2018
Citation: Kim, T.N., Spatz, S.J., Volkening, J.D. 2018. Genomic sequence analysis of Gallid herpesvirus 3 vaccine strain 301B/1 [abstract]. Annual Convention of the American Association of Avian Pathologist, Denver, Colorado, July 14-17, 2018.

Interpretive Summary:

Technical Abstract: Marek’s disease (MD) is a highly contagious lymphoproliferative disease in chicken caused by Gallid herpesvirus 2. Although current vaccines do not block the virus infection, they provide protection against tumor formation and mortality. Turkey herpesvirus (HVT) vaccine is currently used as a vaccine platform for protection against other poultry diseases as well as Marek’s disease. Gallid herpesvirus 3 (GaHV-3) strain 301B/1 has been used as MD vaccine and its efficacy is superior to widely used SB-1 strain when used as a bivalent vaccine with HVT. Full-genome sequence of Gallid herpesvirus 3 vaccine strain 301B/1 was determined by next-generation sequencing with DNA purified from virus capsids. Overall the genome structure is very similar to GaHV-3 strain SB-1, but unlike to SB-1 virus, no LTR sequences were identified in 301B/1 genome. The detail of the analysis will be discussed.