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ARS Home » Southeast Area » New Orleans, Louisiana » Southern Regional Research Center » Cotton Chemistry and Utilization Research » Research » Publications at this Location » Publication #350792

Research Project: Chemical Modification of Cotton for Value Added Applications

Location: Cotton Chemistry and Utilization Research

Title: Structure/function relations of hemostatic nonwoven dressings based on greige cotton

Author
item Edwards, Judson - Vince
item Graves, Elena
item YAGER, DORNE - Virginia Commonwealth University
item DACORTA, JOSEPH - H&h Medical Corporation
item GARY, LAWSON - T J Beall Company
item Reynolds, Michael
item Condon, Brian

Submitted to: Meeting Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 4/1/2018
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: A variety of natural and synthetic fibers are employed in hemostatic dressings. Here we demonstrate the use of greige cotton as a functional fiber, which when combined with hydrophilic and hydrophobic fibers in hydroentangled nonwoven materials, promotes accelerated clotting. A biophysical approach was developed to identify fiber compositions that promote hemostasis. The structure/function characterization of greige cotton-based dressings was based on the relationship of material electrokinetics to the rate of fibrin and clot formation. When coupled to material absorption capacity and wicking determinations, materials that promote a rapid onset of clotting were identified. In vitro assessment of whole materials that promote hemostasis was completed using the Lee White Clotting assay to provide a structure versus function profile of hemostatic activity for selection of leads.