|BERTRAN, KATERI - Consultant|
|KWON, YONG-KUK - Animal And Plant Quarantine Agency|
|TUMPEY, TERRENCE - Centers For Disease Control And Prevention (CDCP) - Canada|
|CLARK, ANDREW - Consultant|
Submitted to: Emerging Infectious Diseases
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/4/2017
Publication Date: 11/1/2017
Publication URL: http://handle.nal.usda.gov/10113/6472228
Citation: Bertran, K., Balzli, C.L., Kwon, Y., Tumpey, T.M., Clark, A., Swayne, D.E. 2017. Airborne transmission of highly pathogenic influenza virus during processing of infected poultry. Emerging Infectious Diseases. 23(11):1806-1814. https://doi.org/10.3201/eid2311.170672.
Interpretive Summary: Human infections with H5N1 highly pathogenic avian influenza (HPAI) virus have occurred following visits to live poultry markets (LPM) within some developing countries. In this study, we demonstrated that processing of HPAI virus infected chickens in a high biocontainment laboratory to emulate a LPM produced virus in the air, and chickens and ferrets breathing this air became infected and died. Processing of infected ducks was less likely to produce virus in the air and reduced the transmission of HPAI virus to others ducks or ferrets. These results demonstrate the mechanism where by poultry and humans become infected through visits to live poultry markets.
Technical Abstract: Human infections with H5N1 highly pathogenic avian influenza (HPAI) virus occur following exposure to virus-infected poultry, often during the slaughter processes. Infectious virus within bioaerosols was detected during laboratory-simulated processing of asymptomatic chickens infected with human- (clades 1 and 2.2.1) and avian-origin (clades 1.1, 2.2, and 2.1) H5N1 viruses. In contrast, the processing of infected ducks was less efficient in generating infectious virus within bioaerosols. Naïve chickens and ferrets exposed to the same air space during the processing of virus-infected chickens became infected and died, suggesting that the slaughter of infected chickens is an efficient source of exposure to avian and mammalian hosts. In contrast, naïve ducks and ferrets exposed to the same air space during processing of virus-infected ducks produced inconsistent infections. The results support a role for airborne transmission of HPAI viruses among poultry and from poultry to humans during home or live-poultry market slaughter processes.