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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #335349
Title: Endemic Poultry Viral Diseases 2016 Research Update

Author
item Day, James
item Spatz, Stephen
item Yu, Qingzhong

Submitted to: United States Animal Health Association Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 10/14/2016
Publication Date: N/A
Citation: N/A

Interpretive Summary: Viral infections of the avian gastrointestinal tract negatively impact poultry production; however, determining the complex etiologies of the viral enteric diseases in poultry has been difficult. Project scientists are continuing to investigate the species specificity, molecular phylogenetics, and pathogenesis of novel viruses initially discovered in the poultry gut using a metagenomic approach. Enteric viral diseases of poultry are responsible for substantial economic losses to the poultry industry in the United States and abroad; however, targeted interventions to control enteric disease are lacking. To discover novel vaccine platforms and vaccination strategies for control of enteric diseases, project scientists are developing tissue tropic multivalent vaccine vectors using Newcastle disease virus (NDV) vaccine strains. Further, the avian alphaherpesviruses--Marek’s disease virus type I and infectious laryngotracheitis virus--are responsible for substantial economic losses to the poultry industry worldwide. To discover novel vaccine platforms we have embarked on two strategies to generate bivalent vaccines against both infectious laryngotracheitis virus (ILTV) and Newcastle disease virus (NDV).

Technical Abstract: Viral infections of the avian gastrointestinal tract negatively impact poultry production; however, determining the complex etiologies of the viral enteric diseases in poultry has been difficult. Project scientists are continuing to investigate the species specificity, molecular phylogenetics, and pathogenesis of novel viruses initially discovered in the poultry gut using a metagenomic approach. Enteric viral diseases of poultry are responsible for substantial economic losses to the poultry industry in the United States and abroad; however, targeted interventions to control enteric disease are lacking. To discover novel vaccine platforms and vaccination strategies for control of enteric diseases, project scientists are developing tissue tropic multivalent vaccine vectors using Newcastle disease virus (NDV) vaccine strains. Further, the avian alphaherpesviruses--Marek’s disease virus type I and infectious laryngotracheitis virus--are responsible for substantial economic losses to the poultry industry worldwide. To discover novel vaccine platforms we have embarked on two strategies to generate bivalent vaccines against both infectious laryngotracheitis virus (ILTV) and Newcastle disease virus (NDV).