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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #334933

Research Project: Molecular Identification and Characterization of Bacterial and Viral Pathogens Associated with Foods

Location: Produce Safety and Microbiology Research

Title: Complete genomic sequence of campylobacter jejuni subsp. jejuni HS:19 penner reference strain

Author
item Parker, Craig
item Huynh, Steven
item Heikema, Astrid - Erasmus Medical Center

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/23/2016
Publication Date: 2/23/2017
Citation: Parker, C., Huynh, S., Heikema, A.P. 2017. Complete genomic sequence of campylobacter jejuni subsp. jejuni HS:19 penner reference strain. Genome Announcements. 5(8):e01701-16. doi: 10.1128/genomeA.01701-16.

Interpretive Summary: Campylobacter jejuni subsp. jejuni (Cjj) infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). It is established that sialylated lipooligosaccharides (LOS) of C. jejuni are a crucial virulence factor in GBS development. Moreover, a few capsular genotypes were significantly associated with GBS. Capsular type Penner HS:19 is among these capsule types shown to be markers for GBS. This study describes the genome of Cjj HS:19 Penner reference strain RM3420. The complete annotated genomic sequences of RM3420 is 1.67 Mbp and possesses a LOS biosynthesis locus predicted to synthesize sialylated LOS molecules. It also harbors a C. jejuni Mu-like prophage that carries the dns gene encoding an extracellular deoxyribonuclease, previously shown to inhibit natural transformation of C. jejuni.

Technical Abstract: Campylobacter jejuni subsp. jejuni (Cjj) infections are a leading cause of foodborne gastroenteritis and the most prevalent antecedent to Guillain-Barré syndrome (GBS). Capsular type Penner HS:19 is among several capsule types shown to be markers for GBS. This study describes the genome of Cjj HS:19 Penner reference strain RM3420.