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Title: Negative data provide weak support for disappearance and restricted emergence/persistence of highly pathogenic influenza A viruses in North American waterfowl

Author
item RAMEY, ANDREW - Us Geological Survey (USGS)
item Spackman, Erica
item TORCHETTI, MIA - Animal And Plant Health Inspection Service (APHIS)
item DELIBERTO, TOM - Animal And Plant Health Inspection Service (APHIS)

Submitted to: Proceedings of the National Academy of Sciences (PNAS)
Publication Type: Other
Publication Acceptance Date: 9/14/2016
Publication Date: 10/17/2016
Citation: Ramey, A., Spackman, E., Torchetti, M., Deliberto, T. 2016. Negative data provide weak support for disappearance and restricted emergence/persistence of highly pathogenic influenza A viruses in North American waterfowl. Proceedings of the National Academy of Sciences. 1-2. doi/10.1073/pnas.1614530113

Interpretive Summary: In their recent paper, Krauss et al. use lack of detection of highly pathogenic (HP) H5 clade 2.3.4.4 (henceforth ‘H5’) influenza A viruses (IAVs) from >22,000 wild bird samples collected in North America (NA) in 2014–2015 to argue that HP H5 IAVs disappeared from waterfowl and that unresolved mechanisms restrict emergence and perpetuation of HP IAVs in natural reservoir species. Here we offer an alternative interpretation.

Technical Abstract: In their recent paper, Krauss et al. use lack of detection of highly pathogenic (HP) H5 clade 2.3.4.4 (henceforth ‘H5’) influenza A viruses (IAVs) from >22,000 wild bird samples collected in North America (NA) in 2014–2015 to argue that HP H5 IAVs disappeared from waterfowl and that unresolved mechanisms restrict emergence and perpetuation of HP IAVs in natural reservoir species. Here we offer an alternative interpretation.