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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #330979
Research Project: Discovery and Development of Natural Products for Pharmaceutical and Agrochemical Applications II

Location: Natural Products Utilization Research

Title: Meroterpenoids with antiproliferative activity from a Hawaiian-plant associated fungus Peyronellaea coffeae-arabicae FT238

Author
item LI, CHUN-SHUN - University Of Hawaii
item REN, GANG - University Of Mississippi
item YANG, BAO-JUN - University Of Hawaii
item MIKLOSSY, GABRIELLA - University Of Hawaii
item TURKSON, JAMES - University Of Hawaii
item FEI, PEIWEN - University Of Hawaii
item DING, YUANQING - University Of Hawaii
item WALKER, LARRY - University Of Mississippi
item CAO, SHUGENG - University Of Hawaii

Submitted to: Organic Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/2/2016
Publication Date: 5/2/2016
Citation: Li, C., Ren, G., Yang, B., Miklossy, G., Turkson, J., Fei, P., Ding, Y., Walker, L.A., Cao, S. 2016. Meroterpenoids with antiproliferative activity from a Hawaiian-plant associated fungus Peyronellaea coffeae-arabicae FT238. Organic Letters. 18(10):2335-8. doi:10.1021/acs.orglett.6b00685.

Interpretive Summary: Three polyketide-sesquiterpene metabolites, along with a new epoxyphomalin analog, have been isolated from the endophytic fungus Peyronellaea coffeae-arabicae FT238 obtained from the native Hawaiian plant Pritchardia lowreyana. Their structures were characterized based on NMR and MS spectroscopic analysis. Their absolute configurations were determined by electronic circular dichroism (ECD). 11-dehydroxy epoxyphomalin A showed antiproliferative activity against OVCAR3, and strongly inhibited

Technical Abstract: Three unusual polyketide-sesquiterpene metabolites peyronellins A-C (1-3), along with the new epoxyphomalin analog 11-dehydroxy epoxyphomalin A (4), have been isolated from the endophytic fungus Peyronellaea cof feae-arabicae FT238, which was isolated from the native Hawaiian plant Pritchardia lowreyana. The structures of compounds 1-4 were characterized based on NMR and MS spectroscopic analysis. The absolute configuration (AC) of the compounds was determined by electronic circular dichroism (ECD). Compound 4 showed antiproliferative activity with an IC50 of 0.5 µM against OVCAR3, and it also strongly inhibited Stat3 at 5 µM.