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ARS Home » Pacific West Area » Pullman, Washington » WHGQ » Research » Publications at this Location » Publication #321575

Research Project: Biology and Biological Control of Root Diseases of Wheat, Barley and Biofuel Brassicas

Location: Wheat Health, Genetics, and Quality Research

Title: New Suppressive System with a Novel Antibiotic Conprimycin

Author
item CHA, JAE-YUL - Gyeongsang National University
item HAN, SANGJO - Gyeongsang National University
item HONG, HEE-JEON - University Of Cambridge
item CHO, HYUNJI - Gyeongsang National University
item KIM, DARAN - Gyeongsang National University
item KWON, YOUNGHO - Gyeongsang National University
item KWON, SOON-KYEONG - Yonsei University
item CRUSEMANN, MAX - University Of California
item LEE, YONG - Gyeongsang National University
item KIM, JIHYUN - Yonsei University
item GIAEVER, GURI - University Of British Columbia
item NISLOW, COREY - University Of British Columbia
item MOORE, BRADLEY - University Of California
item Thomashow, Linda
item Weller, David

Submitted to: International PGPR Workshop
Publication Type: Abstract Only
Publication Acceptance Date: 4/1/2015
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Crops lack genetic resistance to most necrotrophic pathogens. To compensate for this disadvantage, plants recruit antagonistic members of the soil microbiome to defend their roots against pathogens and other pests. The best examples of this microbe-based defense of roots are observed in disease-suppressive soils in which suppressiveness is induced by continuously growing crops that are susceptible to a pathogen, but the molecular basis of most is poorly understood. Here we report the microbial characterization of a Korean soil suppressive to Fusarium wilt of strawberry. In this soil, an attack on strawberry roots by Fusarium oxysporum results in a response by microbial defenders of which Streptomyces appears to be a key component. We also identify the Streptomyces genes responsible for the ribosomal synthesis of a novel heat-stable antifungal thiopeptide antibiotic inhibitory to F. oxysporum and the antibiotic’s mode of action against fungal cell wall biosynthesis. These results provide a framework for studies to elucidate the basis of microbe-based defense systems and soil suppressiveness from the field to the molecular level and highlight the role of natural antibiotics as weapons in the microbial warfare in the rhizosphere that is integral to plant health, vigor and development.