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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #319215

Research Project: Intervention Strategies to Control and Prevent Enteric Viral Diseases of Poultry

Location: Endemic Poultry Viral Diseases Research

Title: Expressing foreign genes by Newcastle disease virus for cancer therapy

Author
item Bai, Fu-liang - Northeast Agricultural University
item Tian, Hui - Northeast Agricultural University
item Yu, Qingzhong
item Ren, Gui-ping - Northeast Agricultural University
item Li, De-shan - Northeast Agricultural University

Submitted to: Molecular Biology
Publication Type: Review Article
Publication Acceptance Date: 7/31/2014
Publication Date: 3/1/2015
Citation: Bai, F., Tian, H., Yu, Q., Ren, G., Li, D. 2015. Expressing foreign genes by Newcastle disease virus for cancer therapy. Molecular Biology. 49(2):171-178. DOI: 10.1134/S0026893315020028.

Interpretive Summary: Newcastle disease virus (NDV), an avian pathogen, has an interesting feature that it can selectively replicate in tumor cells, but not normal cells in humans. Thus, NDV has been used as an anti-cancer agent in preclinical trials. Recently, NDV has been developed as a vector using a reverse genetics technology to express foreign genes to enhance its anti-cancer properties and therapeutic potential for tumor therapy. This paper provides an overview of the current studies on the cytotoxic and anti-cancer effects of recombinant NDV expressing foreign genes (rNDV-FG) via direct tumor cell lyses and immune stimulation. Safety of rNDV-FG as a therapeutic agent for cancer immunotherapy and virotherapy is also discussed.

Technical Abstract: An interesting aspect of Newcastle disease virus (NDV) is the ability to selectively replicate in tumor cells. Recently, using reverse genetics technology to enhance the oncolytic properties and therapeutic potential of NDV for tumor therapy has become popular in immunocompetent carcinoma tumor models. Expressing foreign genes by recombinant NDV (rNDV-FG) has been shown to be more effective in cancer therapy in preclinical studies. This paper provides an overview of the current studies on the cytotoxic and anti-cancer effects of rNDV-FG via direct oncolysis and immune stimulation. Safety of rNDV-FG as a therapeutic agent for cancer immunotherapy and virotherapy is also discussed.