Location: Endemic Poultry Viral Diseases ResearchTitle: S2 expressed from recombinant virus confers broad protection against infectious bronchitis virus Author
|Toro, Haroldo - Auburn University|
|Van Santen, Vicky - Auburn University|
|Joiner, Kellye - Auburn University|
|Ghetas, Aly - Auburn University|
Submitted to: International Symposium on Avian Corona and Pneumoviruses and Complicating Pathogens
Publication Type: Abstract Only
Publication Acceptance Date: 4/7/2014
Publication Date: 6/21/2014
Citation: Toro, H., Yu, Q., van Santen, V., Joiner, K., Ghetas, A. 2014. S2 expressed from recombinant virus confers broad protection against infectious bronchitis virus [abstract]. In: Programme and Abstracts of the 8th International Symposium on Avian Corona- and Pneumoviruses and Complicating Pathogens. 2nd Annual Meeting of the COST Action FA1207, June 17-20-2014. p. 76.
Technical Abstract: We previously demonstrated that overexposing the IBV (infectious bronchitis virus) S2 to the chicken immune system by means of a vectored vaccine, followed by boost with whole virus, protects chickens against IBV showing dissimilar S1. We developed recombinant Newcastle disease virus (NDV) LaSota (rLS) vectoring distinct codon optimized IBV S2 genes (rLS/IBV.S2). The S2 genes were inserted into rLS vectors between the phosphoprotein (P) and matrix (M) genes. Further evidence confirming broad protection conferred by combined vaccination with rLS/IBV.S2 and a commercial attenuated Massachusetts-type vaccine against heterologous challenge will be discussed.