Submitted to: Animal Influenza Virus
Publication Type: Book / Chapter
Publication Acceptance Date: 12/27/2013
Publication Date: 6/12/2014
Citation: Cardona, C., Halvorson, D.A., Brown, J., Pantin Jackwood, M.J. 2014. Conducting influenza virus pathogenesis studies in avian species. In: Spackman, E., editor. Animal Influenza Virus: Methods in Molecular Biology. Volume 1161. London: Humana Press. p. 169-183. Interpretive Summary: The purpose of this chapter is to provide a framework for conducting influenza A virus (IAV) experimental infection studies in avian species. These studies are necessary to understand the host susceptibility, the pathogenesis, the host responses to infection, the mechanisms of transmission of influenza A viruses in avian species. This chapter will address the different elements to take into account when conducting infection studies, including: general guidelines for choosing a virus to use, host selection and many aspects of study design.
Technical Abstract: Avian infection studies with influenza A are an important means of assessing host susceptibility, viral pathogenesis, host responses to infection, mechanisms of transmission and viral pathotype. Complex systems and natural settings may also be explored with carefully designed infection studies. In this chapter, we explore the elements of infection studies, general guidelines for choosing a virus to use, host selection and many aspects of study design.