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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #294269

Research Project: IDENTIFICATION OF DISEASE MECHANISMS AND DEVELOPMENT OF IMPROVED DIAGNOSTICS AND VACCINES FOR BRUCELLOSIS IN LIVESTOCK AND WILDLIFE

Location: Infectious Bacterial Diseases Research

Title: In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.

Author
item Olsen, Steven
item Carlson, Steve - Iowa State University

Submitted to: Antimicrobial Agents and Chemotherapy
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/23/2014
Publication Date: N/A
Citation: N/A

Interpretive Summary: Brucella are intracellular pathogens that causes reproductive losses in livestock and which also causes zoonotic infections in people. In this study, we characterized the effectiveness of antibiotics on various species of Brucella that can also infect people. A new generation antibiotic was equivalent against Brucella as antibiotics that are currently used as treatments for brucellosis. This data will be of interest to people responsible for public health, regulatory personnel, livestock owners, and other parties with interests regarding brucellosis management.

Technical Abstract: Plazomicin is a next-generation aminoglycoside with a potentially improved safety profile compared to other aminoglycosides. This study assessed plazomicin MICs and MBCs in four Brucella spp. reference strains. Like other aminoglycosides and aminocyclitols, plazomicin MBC values equaled MIC values for the majority (three out of four) of the plazomicin-Brucella combinations. This is the first study to document that plazomicin, and related drugs, appear to be significantly bactericidal against Brucella spp. in vitro.