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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Exotic & Emerging Avian Viral Diseases Research » Research » Publications at this Location » Publication #280169

Research Project: Characterization of Protective Host Responses to Avian Influenza Virus Infections in Avian Species

Location: Exotic & Emerging Avian Viral Diseases Research

Title: Serological examination of sera from hyperimmunized chickens and turkeys

Author
item Pedersen, Janice - ANIMAL AND PLANT HEALTH INSPECTION SERVICE (APHIS)
item Kapczynski, Darrell
item Suarez, David
item Hines, N.l. - ANIMAL AND PLANT HEALTH INSPECTION SERVICE (APHIS)
item Killian, M.l. - ANIMAL AND PLANT HEALTH INSPECTION SERVICE (APHIS)
item Schmitt, Beverly - ANIMAL AND PLANT HEALTH INSPECTION SERVICE (APHIS)

Submitted to: International Symposium on Avian Influenza
Publication Type: Abstract Only
Publication Acceptance Date: 6/15/2012
Publication Date: 8/4/2012
Citation: Pedersen, J.C., Kapczynski, D.R., Suarez, D.L., Hines, N., Killian, M., Schmitt, B.J. 2012. Serological examination of sera from hyperimmunized chickens and turkeys [abstract]. International Symposium on Avian Influenza. CDROM.

Interpretive Summary:

Technical Abstract: Detection of avian influenza (AI) H5 and H7 antibody in commercial poultry is a World Organization for Animal Health (OIE) notifiable event and impacts trade. Chickens and turkeys which had been vaccinated with an oil-emulsion H1N1/H3N2 influenza autogenous vaccine were inoculated with inactivated pandemic H1N1 (pH1N1) virus (chickens) and live pH1N1 virus (turkeys) to determine if multiple exposures to pH1N1 virus can result in non-specific hemagglutination-inhibition (HI) reactions against H5 AI. Sera from the hyperimmunized chickens and turkeys and field vaccinated turkeys were tested to evaluate the possibility of cross-reaction to subtypes H1, H2, and H5 AI which genetically fall into a distinct phylogenetic clade. Sera from field turkeys and hyperimmunized chickens and turkeys did result in a small number of positive H5 reactions, but the results do not appear to support cross-reactivity based on a clade-based relationship.