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ARS Home » Southeast Area » Gainesville, Florida » Center for Medical, Agricultural and Veterinary Entomology » Mosquito and Fly Research » Research » Publications at this Location » Publication #254956

Title: Research on New Repellents

item Bernier, Ulrich
item Tsikolia, Maia
item Agramonte, Natasha
item SLAVOV, SVETOSLAV - University Of Florida
item HALL, DENNIS - University Of Florida
item Clark, Gary
item Linthicum, Kenneth - Ken
item KATRITZKY, ALAN - University Of Florida

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 11/9/2009
Publication Date: N/A
Citation: N/A

Interpretive Summary: N/A.

Technical Abstract: The USDA has conducted testing of repellents and toxicants for the past 60 years. The number examined exceeds 30,000 compounds. By examining subsets of these compounds, we hope to develop models and discover new chemicals for personal protection and control of mosquitoes. The primary focus thus far has been on the discovery of novel repellents. Using subsets of acylpiperidines and carboxamides, predictive models were developed that led to the synthesis of novel compounds. The compounds were evaluated using a “cloth patch assay” with human volunteers to determine the duration of repellency efficacy. A total of 29 acylpiperidines and carboxamides repelled mosquitoes from biting for durations longer than the repellency afforded by DEET. Ten of the acylpiperidines repelled bites for over 50 days at the 25 µm dose compared to 7 days repellency for DEET at this dose. These repellents are currently being evaluated against other arthropods of medical importance.