Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 11/3/2009
Publication Date: 2/5/2010
Citation: Manly, S.P., Smillie, T., Hester, J.P., Khan, I., Coudurier, L. 2010. Unique Discovery Aspects of Utilizing Botanical Sources in Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery. Taosheng Chen, Ed., CRC Press, Boca Raton, FL. PP 213-232. Interpretive Summary: This book chapter is an overview of three topics, (1) the diversity of product types derived from botanical sources, (2) screening and database management for screening for activity in screening assays and (3) botanical product regulation in the United States.
Technical Abstract: Because of a long tradition of use in humans, botanicals have many unique advantages to offer as sources of natural products with pharmaceutical influence, especially in terms of opportunities for the development of diverse botanical products. This chapter outlines their use in screening programs, including distinctive informatics needs and certain paths/modes of development inherent to botanicals vs other sources of natural product leads. The uses of botanical derived products continues to change and grow from the traditional medicinal uses to nutraceutical use, dietary supplements, "functional foods", food additives, "sports and energy" food/drinks and drugs (both small molecules and complex mixtures). The perspectives and goals of practitioners of botanical research are quite diverse. Many research groups seeking to identify particular activities in plant extracts have adopted the technology developed in the pharamaceutical companies for empirical discovery, high throughput screening and its data management underpinning.