Submitted to: Journal of Natural Products
Publication Type: Peer reviewed journal
Publication Acceptance Date: 10/1/2008
Publication Date: 12/9/2008
Citation: Stanikunaite, R., Radwan, M.M., Trappe, J.M., Fronczek, F., Ross, S.A. 2008. Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity. Journal of Natural Products. 71(12):2077-2079. Interpretive Summary: Three new and two known lanostane triterpenes had been isolated and chemically identified from the Truffle mushroom Astraeus pterdis. The antituberculosis activity of the isolates was evaluated.
Technical Abstract: Bioassay-guided fractionation of the EtOH extract of the Truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes, and phenylalanine betaine (6). The structures of the isolates were elucidated based on 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. The antituberculosis activity of the isolates was evaluated. Compounds 5 and 1 showed moderate antituberculosis activity with MIC values of 34.0 and 58.0 µg/mL, respectively.