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Title: Flavan-3-ol-phenylpropanoid Conjugates from Anemopaegma arvense and Their Antioxident Activites

Author
item Tabanca, Nurhayat
item PAWAR, RAHUL - UNIVERSITY OF MISSISSIPPI
item FERREIRA, DANEEL - UNIVERSITY OF MISSISSIPPI
item MARAIS, JANNIE P. - UNIVERSITY OF MISSISSIPPI
item KHAN, SHABANA - UNIVERSITY OF MISSISSIPPI
item Wedge, David
item KHAN, IKHLAS - UNIVERSITY OF MISSISSIPPI

Submitted to: Planta Medica
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/8/2007
Publication Date: 7/1/2007
Citation: Tabanca, N., Pawar, R.S., Ferreira, D., Marais, J.J., Khan, S.I., Wedge, D.E., Khan, I.A. 2007. Flavan-3-ol-phenylpropanoid Conjugates from Anemopaegma arvense and Their Antioxident Activites. Planta Medica. 73:1107-1111.

Interpretive Summary: Erythroxylum catuaba is a vigorous-growing, small tree that produces yellow and orange flowers and small, dark yellow, oval-shaped, inedible fruit. It grows in the northern part of Brazil in Amazonas. "Catuaba" is the name given to a popular herbal medicine from Brazil and it has been attributed with analgesic, central nervous system stimulant, tonic and aphrodisiac properties. A new and three known flavan-3-ol type phenylpropanoids were isolated from the stem bark of Erythroxylum catuaba. Compounds 1-4 were subsequently evaluated for their antioxidant, anti-inflammatory, cytotoxicity, antimalarial and antimicrobial activities.

Technical Abstract: A new (1, catuabin A) and three known flavan-3-ol type phenylpropanoids, cinchonain Ia (2), cinchonain IIa (3), and kandelin A1 (4) were isolated from the stem bark of Erythroxylum catuaba. The structures of the compounds were determined by a combination of spectroscopic techniques. Isolated compounds were subsequently evaluated for their antioxidant, anti-inflammatory, cytotoxicity, antimalarial and antimicrobial activities. Compounds 1 and 3 exhibited stronger antioxidant activity than 2 and 4. However, anti-inflammatory, cytotoxic, antimalarial and antimicrobial activities were not observed for any of these compounds.