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United States Department of Agriculture

Agricultural Research Service

Title: Flavan-3-ol-phenylpropanoid Conjugates from Anemopaegma arvense and Their Antioxident Activites)

Author
item Tabanca, Nurhayat
item Pawar, Rahul
item Ferreira, Daneel
item Marais, Jannie p.
item Khan, Shabana
item Wedge, David
item Khan, Ikhlas

Submitted to: Planta Medica
Publication Type: Peer reviewed journal
Publication Acceptance Date: 6/8/2007
Publication Date: 7/1/2007
Citation: Tabanca, N., Pawar, R.S., Ferreira, D., Marais, J.J., Khan, S.I., Wedge, D.E., Khan, I.A. 2007. Flavan-3-ol-phenylpropanoid Conjugates from Anemopaegma arvense and Their Antioxident Activites. Planta Medica. 73:1107-1111.

Interpretive Summary: Erythroxylum catuaba is a vigorous-growing, small tree that produces yellow and orange flowers and small, dark yellow, oval-shaped, inedible fruit. It grows in the northern part of Brazil in Amazonas. "Catuaba" is the name given to a popular herbal medicine from Brazil and it has been attributed with analgesic, central nervous system stimulant, tonic and aphrodisiac properties. A new and three known flavan-3-ol type phenylpropanoids were isolated from the stem bark of Erythroxylum catuaba. Compounds 1-4 were subsequently evaluated for their antioxidant, anti-inflammatory, cytotoxicity, antimalarial and antimicrobial activities.

Technical Abstract: A new (1, catuabin A) and three known flavan-3-ol type phenylpropanoids, cinchonain Ia (2), cinchonain IIa (3), and kandelin A1 (4) were isolated from the stem bark of Erythroxylum catuaba. The structures of the compounds were determined by a combination of spectroscopic techniques. Isolated compounds were subsequently evaluated for their antioxidant, anti-inflammatory, cytotoxicity, antimalarial and antimicrobial activities. Compounds 1 and 3 exhibited stronger antioxidant activity than 2 and 4. However, anti-inflammatory, cytotoxic, antimalarial and antimicrobial activities were not observed for any of these compounds.

Last Modified: 8/24/2016
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