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Title: Effect of Essential Oils and Isolated Compounds from Pimpinella Species on NF-kB: A Target for Antiinflammatory Therapy

Author
item Tabanca, Nurhayat
item MA, GUOYI - UNIVERSITY OF MISSISSIPPI
item PASCO, DAVID - UNIVERSITY OF MISSISSIPPI
item BEDIR, ERDAL - EGE UNIVERSITY-TURKEY
item KIRIMER, NESE - ANADOLU UNIVERSITY-TURKEY
item BASER, K. HUSNU - ANADOLU UNIVERSITY-TURKEY
item KHAN, IKHLAS - UNIVERSITY OF MISSISSIPPI
item KHAN, SHABANA - UNIVERSITY OF MISSISSIPPI

Submitted to: Phytotherapy Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/1/2007
Publication Date: 4/20/2007
Citation: Tabanca, N., Ma, G., Pasco, D.S., Bedir, E., Kirimer, N., Baser, K.C., Khan, I.A., Khan, S.I. 2007. Effect of Essential Oils and Isolated Compounds from Pimpinella Species on NF-kB: A Target for Antiinflammatory Therapy. Phytotherapy Research. 21:741-745.

Interpretive Summary: Acquisition of drug resistance in cancer sells is the major cause of the inefficacy of cancer therapy. Activation of the NF-kB transcription factor is one of the signaling pathways that contribute to the resistance of cancer cells to radio and chemotherapies. Twelve Pimpinella essential oils and twenty one isolated compounds were screened for their anti-inflammatory activity against NF-kB. Out of twenty one pure compounds; only five compounds inhibited NF-kB mediated transcription. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention specially those related to inflammation.

Technical Abstract: Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kB mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-kB mediated transcription. Especially roots of P corymbosa, P tragium and P rhodanta showed potent activities with IC50 values of 2, 3 and 6 ug/ml, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate), and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kB mediated transcription with IC50 value of 5.5, 1.2, 0.01, 3.6, and 11 ug/ml, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention specially those related to inflammation.