Submitted to: Marine Biotechnology
Publication Type: Peer reviewed journal
Publication Acceptance Date: 9/22/2004
Publication Date: 11/1/2004
Citation: Kasanah, N., Rao, K., Yousaf, M., Wedge, D.E., Hill, R.T., Hamann, M.T. 2004. Biotransformation studies of the manzamine alkaloids. Marine Biotechnology. 6:268-272. Interpretive Summary: Manzamines are a group of alkaloids derived from marine sponges that possess a complex heterocyclic ring structure attached to a ß-carboline moiety. The manzamine alkaloids have a diverse range of bioactivity including antitumor and cytotoxicity, anti-inflammatory, antiinfective and antiparasitic, with the greatest potential utility against malaria.
Technical Abstract: The manzamines are complex, polycyclic, marine derived alkaloids that are important as pharmaceutical agents due to their activity as antimalarial, antituberculosis, and antitumor drug-leads. In order to understand the metabolism and biogenesis of the manzamines, we examined the biotransformation of manzamine using a number of microorganisms. Our biotransformation studies have focused both on the improvement of the activity and reduced toxicity of the manzamines that may be generated by sponge-associated microbes. Biotransformation studies of 8-hydroxymanzamine A, manzamine F, and manzamine X showed that the biotransformation products generated in our laboratory are the same as further oxidized manzamine analogs isolated directly from the sponge.