|Straus, David - Dave|
Submitted to: Investigational New Animal Drugs Meeting - Book of Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 8/3/2001
Publication Date: 8/3/2001
Citation: STRAUS, D.L., GRIFFIN, B.R. NEW EVIDENCE SUPPORTING THE APPROVAL OF POTASSIUM PERMANGANATE AS A THERAPEUTANT TO TREAT ICHTHYOPHTHIRIASIS IN CHANNEL CATFISH.. INVESTIGATIONAL NEW ANIMAL DRUGS MEETING - BOOK OF ABSTRACTS. 2001. v.7. p.G1-G5. Interpretive Summary:
Technical Abstract: Free-swimming Ichthyophthirius multifiliis theronts were exposed to concentrations of KMnO4 in well water in 96-well plates and observed for 4 h to determine the acute toxicity. A concentration of 0.9 mg KMnO4/L caused greater than 95% mortality of the theronts in 45 min; the 4 h-LC50 value was estimated to be 0.77 mg/L. Juvenile channel catfish Ictalurus punctatus were exposed to 10,000 theronts/L of well water and immediately treated with a single dose of KMnO4 to determine the concentration needed to prevent the establishment of ichthyophthiriasis. The lowest effective dose of KMnO4 was 1.0 mg/L. In another study designed to determine the concentration needed to stop an active epizootic, fish were infested with I. multifiliis and allowed to develop immature trophonts. They were then moved to individual static containers with 2 L of filtered well water and were treated with KMnO4 daily for 10 days; water was exchanged daily prior to treatment. The lowest effective dose (dose required to eliminate trophonts) of KMnO4 was 1.25 mg/L. These results indicate that low concentrations of KMnO4 are effective for controlling I. multifiliis in clean water. However, effective treatment of pond water will be strongly influenced by detoxication of KMnO4 based on the concentration of easily oxidizable substances in the water.