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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » People & Locations » Cristina Cunha

Cristina Cunha
Animal Disease Research
Veterinary Medical Officer

Phone: (509) 335-6059
Fax: (509) 335-8328

3003 ADBF, WSU
PULLMAN, WA 991646630
Projects
Genetic Impact and Improved Diagnostics for Sheep and Goat Transmissible Spongiform Encephalopathies
In-House Appropriated (D)
  Accession Number: 431730
Diagnostic and Control Strategies for Malignant Catarrhal Fever
In-House Appropriated (D)
  Accession Number: 431737

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
A review of the epidemiological, clinical, and pathological aspects of sheep-associated malignant catarrhal fever in Brazil Reprint Icon ()
Headley, S.A., Oliveria, T.E.S., Cunha, C.W. 2020. A review of the epidemiological, clinical, and pathological aspects of sheep-associated malignant catarrhal fever in Brazil. Brazilian Journal of Microbiology. https://doi.org/10.1007/s42770-020-00273-6.
Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever Reprint Icon - (Peer Reviewed Journal)
Headley, S.A., Oliveria, T.E.S., Li, H., Lisbôa, J.A.N., Queiroz, G.R., Fritzen, J.T.T., Flores, E.F., Alfieri, A.A., Cunha, C.W. 2019. Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever. Journal of Comparative Pathology. 174:86-98. https://doi.org/10.1016/j.jcpa.2019.11.002.
Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus Reprint Icon - (Peer Reviewed Journal)
Cunha, C.W., Slater, O.M., Macbeth, B., Duignan, P.J., Warren, A., Highland, M.A., Li, H. 2019. Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus. Virus Research. 272. https://doi.org/10.1016/j.virusres.2019.197729.
A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development Reprint Icon - (Peer Reviewed Journal)
Cunha, C.W., O'Toole, D., Taus, N.S., Shringi, S., Knowles, D.P., Li, H. 2019. A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development. Current Clinical Microbiology Reports. 6:148-155. https://doi.org/10.1007/s40588-019-00126-3.
In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues Reprint Icon - (Peer Reviewed Journal)
Pesavento, P., Cunha, C.W., Li, H., Jackson, K., O'Toole, D. 2018. In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues. Veterinary Pathology. 56(1):78-86. https://doi.org/10.1177/0300985818798085.
Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2 Reprint Icon - (Peer Reviewed Journal)
Pesavento, P., Dange, R., Estrada, M., Dasjerdi, A., Pérez, V., Laroca, A., Silván, J., Diab, S., Jackson, K., Phillips, I., Li, H., Cunha, C.W., Wessels, M. 2018. Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2. Veterinary Pathology. 56:(1)87-92. https://doi.org/10.1177/0300985818795166.
Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay Reprint Icon - (Peer Reviewed Journal)
Alhajri, S.M., Cunha, C.W., Knowles, D.P., Li, H., Taus, N.S. 2018. Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay. PLoS One. 13(7):30200130. https://doi.org/10.1371/journal.pone.0200130.
Moose (alces alces) mortality associated with caprine herpesvirus 2 (CPHV-2) in a zoological collection Reprint Icon - (Peer Reviewed Journal)
Seeley, K., Junge, R., Jennings, R., Cunha, C.W., Li, H. 2018. Moose (alces alces) mortality associated with caprine herpesvirus 2 (CPHV-2) in a zoological collection. Journal of Zoo and Wildlife Medicine. 49(3):774-778. https://doi.org/10.1638/2016-0207.1.
High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb Reprint Icon - (Peer Reviewed Journal)
Phillips, I.L., Cunha, C.W., Galbraith, D., Highland, M.A., Bildfell, R.J., Li, H. 2018. High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/1040638718766976.
Ovine herpesvirus 2 glycoproteins B, H, and L are sufficient for, and viral glycoprotein Ov8 can enhance, cell-cell membrane fusion - (Peer Reviewed Journal)
Alhajri, S.M., Cunha, C.W., Nicola, A.V., Aguilar, H.C., Li, H., Taus, N.S. 2017. Ovine herpesvirus 2 glycoproteins B, H, and L are sufficient for, and viral glycoprotein Ov8 can enhance, cell-cell membrane fusion. Journal of Virology. doi: 10.1128/JVI.02454-16.
Alcelaphine gammaherpesvirus 1-induced malignant catarrhal fever in a Watusi (bos taurus africanus) steer in a North American game park Reprint Icon - (Peer Reviewed Journal)
Bildfell, R.J., Li, H., Alcantar, B., Cunha, C.W., Bradway, D.S., Thomas, K.S. 2017. Alcelaphine gammaherpesvirus 1-induced malignant catarrhal fever in a Watusi (bos taurus africanus) steer in a North American game park. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177?1040638717708392.
Sheep-associated malignant catarrhal fever-like skin disease in a free-ranging bighorn sheep (Ovis canadensis), Alberta, Canada - (Peer Reviewed Journal)
Slater, O.M., Kennedy-Peters, J., Lejeune, M., Gummer, D., Macbeth, B., Warren, A., Joseph, T., Li, H., Cunha, C.W., Duignan, P.J. 2016. Sheep-associated malignant catarrhal fever-like skin disease in a free-ranging bighorn sheep (Ovis canadensis), Alberta, Canada. Journal of Wildlife Diseases. 53(1):153-158.
Replacement of glycoprotein B in alcelaphine herpesvirus 1 by its ovine herpesvirus 2 homolog: Implications in vaccine development for sheep-associated malignant catarrhal fever - (Peer Reviewed Journal)
Cunha, C.W., Taus, N.S., Dewals, B.G., Vanderplasschen, A., Knowles, D.P., Li, H. 2016. Replacement of glycoprotein B in alcelaphine herpesvirus 1 by its ovine herpesvirus 2 homolog: Implications in vaccine development for sheep-associated malignant catarrhal fever. mSphere. doi:10.1128/mSphere.00108-16.
Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever - (Peer Reviewed Journal)
Nelson, D.D., Taus, N.S., Schneider, D.A., Cunha, C.W., Davis, W.C., Brown, W.C., Li, H., O'Toole, D., Oaks, L.J. 2013. Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Veterinary Microbiology. doi: 10.1016/j.vetmic.2013.07.021.
Are rabbits a suitable model to study sheep-associated malignant catarrhal in susceptible hosts? - (Peer Reviewed Journal)
Cunha, C.W., O'Toole, D., Taus, N.S., Knowles Jr, D.P., Li, H. 2013. Are rabbits a suitable model to study sheep-associated malignant catarrhal in susceptible hosts? Veterinary Microbiology. 163(3-4):358-363.
Development of an in vivo system to measure antibody-blocking of ovine herpesvirus 2 entry - (Peer Reviewed Journal)
Li, H., Cunha, C.W., O'Toole, D., Nicola, A.V., Knowles Jr, D.P., Taus, N.S. 2013. Development of an in vivo system to measure antibody-blocking of ovine herpesvirus 2 entry. Journal of Virological Methods. 188(1-2):104-107.
Goats are a potential reservoir for the herpesvirus (MCFV-WTD),causing malignant catarrhal fever in deer - (Peer Reviewed Journal)
Li, H., Cunha, C.W., Abbitt, B., Demaar, T.W., Lenz, S., Hayes, J.R., Taus, N.S. 2013. Goats are a potential reservoir for the herpesvirus (MCFV-WTD),causing malignant catarrhal fever in deer. Journal of Zoo and Wildlife Medicine. 44(2):484-486.
Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever - (Peer Reviewed Journal)
Cunha, C.W., Gailbreath, K.L., O'Toole, D., Knowles Jr, D.P., Schneider, D.A., White, S.N., Taus, N.S., Davis, C.J., Davis, W.C., Li, H. 2012. Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary Microbiology. 159:307-319.
Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization - (Peer Reviewed Journal)
Li, H., Brooking, A., Cunha, C.W., Highland, M.A., O'Toole, D., Knowles Jr, D.P., Taus, N.S. 2012. Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization. Veterinary Microbiology. 159(3-4):485-489. doi:10.1016/j.vetmic.2012.04.016.
Malignant catarrhal fever: understanding molecular diagnostics in context of epidemiology Reprint Icon - (Peer Reviewed Journal)
Li, H., Cunha, C.W., Taus, N.S. 2011. Malignant catarrhal fever: understanding molecular diagnostics in context of epidemiology. International Journal of Molecular Sciences. 10:6881-6893.
Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits Reprint Icon - (Peer Reviewed Journal)
Li, H., Cunha, C.W., Gailbreath, K.L., O'Toole, D., White, S.N., Vanderplasschen, A., Dewals, B., Knowles Jr, D.P., Taus, N.S. 2011. Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits. Veterinary Microbiology. 150(3-4):270-7.
Development of a Multiplex Real-Time PCR for Detection and Differentiation of Malignant Catarrhal Fever Viruses in Clinical Samples - (Peer Reviewed Journal)
Cunha, C.W., Otto, L., Taus, N.S., Knowles Jr, D.P., Li, H. 2009. Development of a Multiplex Real-Time PCR for Detection and Differentiation of Malignant Catarrhal Fever Viruses in Clinical Samples. Journal of Clinical Microbiology. 47(8):2586-2589.
Experimental infection of rabbits with ovine herpesvirus 2 from sheep nasal secretions - (Peer Reviewed Journal)
Gailbreath, K.L., Taus, N.S., Cunha, C.W., Knowles Jr, D.P., Li, H. 2008. Experimental infection of rabbits with ovine herpesvirus 2 from sheep nasal secretions. Veterinary Microbiology. 132:65-73.
Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep - (Peer Reviewed Journal)
Li, H., Cunha, C.W., Davies, C.J., Gailbreath, K.L., Knowles Jr, D.P., Oaks, J.L., Taus, N.S. 2008. Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep. Journal of General Virology. 89(7):1699-1708.
Detection of ovine herpesvirus 2 major capsid gene transcripts as an indicator of virus replication in shedding sheep and clinically affected animals - (Peer Reviewed Journal)
Cunha, C.W., Traul, D., Taus, N.S., Oaks, L., O'Toole, D., Davitt, C.M., Li, H. 2008. Detection of ovine herpesvirus 2 major capsid gene transcripts as an indicator of virus replication in shedding sheep and clinically affected animals. Virus Research. 132(1-2):69-75.