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Cari Hearn
Endemic Poultry Viral Diseases Research
Veterinary Medical Officer

Phone: (269) 325-1023
Fax:

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Projects
Influence of Vaccines, Host Genetics and Pathogen Mutation Rates on the Evolutionary Dynamics of Infectious Diseases - Purdue
Cooperative Agreement (A)
  Accession Number: 439583
Elucidation of Molecular Determinants of Avian Herpesviruses Virulence and Evolution to Inform the Development of Safe and Effective Vaccines
In-House Appropriated (D)
  Accession Number: 441124
Enhancing Genetic Resistance and Vaccinal Response to Control Marek's Disease, Infectious Laryngotracheitis, and Infectious Bursal Disease in Chicken
In-House Appropriated (D)
  Accession Number: 443180
Influence of Vaccines, Host Genetics, and Pathogen Mutation Rates on the Evolutionary Dynamics of Infectious Diseases - Berlin
Non-Assistance Cooperative Agreement (S)
  Accession Number: 439572

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Efficacy of recombinant Marek’s disease vaccine 301B/1 expressing membrane-anchored chicken interleukin-15 - (Peer Reviewed Journal)
Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence Reprint Icon - (Peer Reviewed Journal)
Kim, T.N., Hearn, C.J., Mays, J.K., Velez-Irizarry, D., Reddy, S.M., Spatz, S.J., Cheng, H.H., Dunn, J.R. 2023. Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence. Viruses. 15(11):2263. https://doi.org/10.3390/v15112263.
A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants Reprint Icon - (Peer Reviewed Journal)
Rice, E.S., Alberdi, A., Alfieri, J., Athery, G., Balacco, J.R., Bardou, P., Blackmon, H., Charles, M., Cheng, H.H., Fedrigo, O., Fiddaman, S., Formenti, G., Frantz, L., M. Thomas, G.P., Hearn, C.J., Jarvis, E.D., Klopp, C., Marcos, S., Velez-Irizarry, D., Xu, L., Warren, W.C., Mason, A.S. 2023. A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants. BMC Biology. 21(267). https://doi.org/10.1186/s12915-023-01758-0.
The immune cell landscape and response of Marek's disease resistant and susceptible chickens infected with Marek's disease virus Reprint Icon - (Peer Reviewed Journal)
Warren, W.C., Rice, E.S., Meyer, A., Hearn, C.J., Steep, A., Hunt, H.D., Monson, M.S., Lamont, S.J., Cheng, H.H. 2023. The immune cell landscape and response of Marek's disease resistant and susceptible chickens infected with Marek's disease virus. Scientific Reports. 13. Article 5355. https://doi.org/10.1038/s41598-023-32308-x.
Contribution of the TCR beta repertoire to Marek's disease genetic resistance in chicken Reprint Icon - (Peer Reviewed Journal)
Hearn, C.J., Cheng, H.H. 2023. Contribution of the TCR beta repertoire to Marek's disease genetic resistance in chicken. Viruses. 15(3):607. https://doi.org/10.3390/v15030607.
Progress toward an immune cell atlas in the chicken - (Abstract Only)
Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection Reprint Icon - (Peer Reviewed Journal)
Conrad, S.J., Mays, J.K., Hearn, C.J., Dunn, J.R. 2023. Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection. Avian Diseases. 67(1):102-107. https://doi.org/10.1637/aviandiseases-D-22-00072.
Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus Reprint Icon - (Peer Reviewed Journal)
Xing, N., Hofler, T., Hearn, C.J., Nascimento, M., Camps Paradell, G., Mcmahon, D.P., Kunec, D., Cheng, H.H., Trimpert, J., Osterrieder, N. 2022. Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus. Virus Evolution. 8(2):veac099. https://doi.org/10.1093/ve/veac099.
Identification and validation of Ikaros (IKZF1) as a cancer driver gene for Marek’s disease virus-induced lymphomas Reprint Icon - (Peer Reviewed Journal)
Steep, A., Hildebrandt, E.C., Xu, H., Hearn, C.J., Frishman, D., Niikura, M., Dunn, J.R., Kim, T.N., Conrad, S.J., Muir, W.M., Cheng, H.H. 2022. Identification and validation of Ikaros (IKZF1) as a cancer driver gene for Marek’s disease virus-induced lymphomas. Microorganisms. 10(2):401. https://doi.org/10.3390/microorganisms10020401.
Vaccinal efficacy of recombinant Marek’s disease vaccine 301B/1 expressing chicken interleukin-15 Reprint Icon - (Peer Reviewed Journal)
Kim, T.N., Hearn, C.J. 2022. Vaccinal efficacy of recombinant Marek’s disease vaccine 301B/1 expressing chicken interleukin-15. Avian Diseases. 66(1):79-84. https://doi.org/10.1637/21-00089.
B cells do not play a role in vaccine-mediated immunity against Marek's disease Reprint Icon - (Peer Reviewed Journal)
Heidari, M., Zhang, H., Hearn, C.J., Sunkara, L. 2021. B cells do not play a role in vaccine-mediated immunity against Marek's disease. Vaccine. 10:100128. https://doi.org/10.1016/j.jvacx.2021.100128.
Comparison of Marek's disease virus challenge strains and bird types for vaccine licensing Reprint Icon - (Peer Reviewed Journal)
Dunn, J.R., Mays, J.K., Hearn, C.J., Hartman, A. 2021. Comparison of Marek's disease virus challenge strains and bird types for vaccine licensing. Avian Diseases. 65(2):241-249. https://doi.org/10.1637/aviandiseases-D-20-00122.
Immune-tolerance mediated neuropathogenicity of Marek's disease vaccines - (Abstract Only)
The Secretion of Type I Interferons as a Primary Determinant of Susceptibility to Marek’s Disease Virus in Chickens - (Abstract Only)
Codon deoptimization of UL54 in meq-deleted Marek's disease vaccine candidate eliminates lymphoid atrophy but reduces vaccinal protection Reprint Icon - (Peer Reviewed Journal)
Conrad, S.J., Hearn, C.J., Silva, R.F., Dunn, J.R. 2020. Codon deoptimization of UL54 in meq-deleted Marek's disease vaccine candidate eliminates lymphoid atrophy but reduces vaccinal protection. Avian Diseases. 64(3):243-246. https://doi.org/10.1637/aviandiseases-D-19-00166.
Role of the Chicken T Cell Receptor-Beta Repertoire in Genetic Resistance to Marek's Disease - (Abstract Only)
Attenuation of Marek’s disease virus by codon pair deoptimization of core herpesvirus genes Reprint Icon - (Peer Reviewed Journal)
Conrad, S.J., Silva, R.F., Hearn, C.J., Climans, M., Dunn, J.R. 2018. Attenuation of Marek’s disease virus by codon pair deoptimization of core herpesvirus genes. Virology. 516:219-226. https://doi.org/10.1016/j.virol.2018.01.020.
Differential TCR Vbeta Usage in the Peripheral T Cells of Chickens Resistant and Susceptible to Marek’s Disease - (Abstract Only)
Expression of Marek's disease virus oncoprotein Meq during infection in the natural host Reprint Icon - (Peer Reviewed Journal)
Tai, S., Hearn, C.J., Umthong, S., Agafitei, O., Cheng, H.H., Dunn, J.R., Niikura, M. 2017. Expression of Marek's disease virus oncoprotein Meq during infection in the natural host. Virology. 503:103-113. doi:10.1016/j.virol.2017.01.011.