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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #74725
Title: REGULATION OF BOVINE INTERLEUKIN-1 RECEPTORS

Author
item YU, P - UNIV. WISCONSIN-MADISON
item SCHULER, L - UNIV. WISCONSIN-MADISON
item REJMAN, J - UNIV. WISCONSIN-MADISON
item CHEN, H - UNIV. WISCONSIN-MADISON
item GOSINK, K - UNIV. WISCONSIN-MADISON
item Kehrli Jr, Marcus
item PELAN, LISA - IA STATE UNIV., AMES, IA
item CZUPRYNSKI, C - UNIV. WISCONSIN-MADISON

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 11/6/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Interleukin-1 (IL-1) is a key mediator in inflammation and the immune response that is produced by mononuclear phagocytes and other cells. Among its many biological activities, IL-1 plays a pivotal role in driving the proliferation and activation of lymphocytes. The IL-1 family consists of three ligands (IL-1alpha, IL-1beta, and the IL-1 receptor antagonist) and two receptors (type I and type II). Studies of IL-1 receptors (IL-1R) on human and rodent cells indicate that the type I IL-1R receptor, which is larger and has a long cytoplasmic tail, is the active receptor that mediates signal transduction. In contrast, the type II IL-1R is smaller, lacks a cytoplasmic tail, and acts as a "decoy" receptor on the cell-surface and when shed into the extracellular fluid. Previous results suggested that there may be a relationship between the stimulation of T-cells by either IL-1alpha or IL-1beta, and the type of T helper cells cytokine profile (TH1 versus TH2) that was expressed. There is also evidence that the biological responses elicited by IL-1 are, in turn, influenced by the TH cytokine profile. For example, human neutrophils incubated with the TH2 cytokine IL-4 substantially upregulate the type II IL-1R.